Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yafW-ykfI/CbtA-CbeA |
Location | 3579005..3579684 | Replicon | chromosome |
Accession | NZ_CP043193 | ||
Organism | Escherichia coli O16:H48 strain PG20180063 |
Toxin (Protein)
Gene name | ykfI | Uniprot ID | P77692 |
Locus tag | FYA14_RS17575 | Protein ID | WP_000854672.1 |
Coordinates | 3579005..3579346 (-) | Length | 114 a.a. |
Antitoxin (Protein)
Gene name | yafW | Uniprot ID | Q47684 |
Locus tag | FYA14_RS17580 | Protein ID | WP_000070395.1 |
Coordinates | 3579367..3579684 (-) | Length | 106 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FYA14_RS23230 | 3574591..3574683 | + | 93 | Protein_3418 | sigma factor-binding protein Crl | - |
FYA14_RS17555 | 3574722..3575777 | - | 1056 | WP_000749863.1 | phosphoporin PhoE | - |
FYA14_RS17560 | 3576065..3577168 | + | 1104 | WP_001285288.1 | glutamate 5-kinase | - |
FYA14_RS17565 | 3577180..3578433 | + | 1254 | WP_000893278.1 | glutamate-5-semialdehyde dehydrogenase | - |
FYA14_RS17575 | 3579005..3579346 | - | 342 | WP_000854672.1 | type IV toxin-antitoxin system toxin YkfI | Toxin |
FYA14_RS17580 | 3579367..3579684 | - | 318 | WP_000070395.1 | type IV toxin-antitoxin system antitoxin YafW | Antitoxin |
FYA14_RS17585 | 3579703..3579924 | - | 222 | WP_000691994.1 | DUF987 domain-containing protein | - |
FYA14_RS17590 | 3579933..3580409 | - | 477 | WP_000811693.1 | RadC family protein | - |
FYA14_RS17595 | 3580425..3580883 | - | 459 | WP_000211838.1 | antirestriction protein | - |
FYA14_RS17600 | 3580981..3581220 | - | 240 | WP_000194654.1 | DUF905 domain-containing protein | - |
FYA14_RS17605 | 3581297..3581764 | - | 468 | WP_001547765.1 | hypothetical protein | - |
FYA14_RS17610 | 3581787..3582230 | - | 444 | WP_000824223.1 | hypothetical protein | - |
FYA14_RS17615 | 3582230..3582457 | - | 228 | WP_001548158.1 | hypothetical protein | - |
FYA14_RS17620 | 3582453..3582644 | - | 192 | Protein_3431 | DeoR family transcriptional regulator | - |
FYA14_RS17625 | 3582861..3583682 | - | 822 | WP_000197389.1 | DUF945 domain-containing protein | - |
FYA14_RS17630 | 3583774..3584637 | - | 864 | WP_001065553.1 | GTPase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 3578785..3597648 | 18863 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12905.01 Da Isoelectric Point: 9.6543
>T137575 WP_000854672.1 NZ_CP043193:c3579346-3579005 [Escherichia coli O16:H48]
MKTLPAITQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR
MKTLPAITQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR
Download Length: 342 bp
>T137575 NZ_CP043193:c3579346-3579005 [Escherichia coli O16:H48]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11939.59 Da Isoelectric Point: 6.7391
>AT137575 WP_000070395.1 NZ_CP043193:c3579684-3579367 [Escherichia coli O16:H48]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFILQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFILQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR
Download Length: 318 bp
>AT137575 NZ_CP043193:c3579684-3579367 [Escherichia coli O16:H48]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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