Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yjhX-yjhQ/YjhX-GNAT |
| Location | 4006420..4007234 | Replicon | chromosome |
| Accession | NZ_CP043191 | ||
| Organism | Escherichia coli O16:H48 strain PG20180173 | ||
Toxin (Protein)
| Gene name | yjhX | Uniprot ID | S1PA82 |
| Locus tag | FYA15_RS19635 | Protein ID | WP_001054376.1 |
| Coordinates | 4006420..4006677 (+) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | yjhQ | Uniprot ID | U9Z4B8 |
| Locus tag | FYA15_RS19640 | Protein ID | WP_001309181.1 |
| Coordinates | 4006689..4007234 (+) | Length | 182 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FYA15_RS19615 | 4001708..4002814 | + | 1107 | WP_001309184.1 | N-acetylneuraminate epimerase | - |
| FYA15_RS19620 | 4002879..4003859 | + | 981 | WP_000991438.1 | 9-O-acetyl-N-acetylneuraminic acid deacetylase | - |
| FYA15_RS19625 | 4004442..4005682 | - | 1241 | Protein_3827 | helicase YjhR | - |
| FYA15_RS19630 | 4005798..4006043 | + | 246 | Protein_3828 | GNAT family N-acetyltransferase | - |
| FYA15_RS19635 | 4006420..4006677 | + | 258 | WP_001054376.1 | hypothetical protein | Toxin |
| FYA15_RS19640 | 4006689..4007234 | + | 546 | WP_001309181.1 | N-acetyltransferase | Antitoxin |
| FYA15_RS19645 | 4007290..4008036 | + | 747 | WP_000354251.1 | class I SAM-dependent methyltransferase | - |
| FYA15_RS19650 | 4008205..4008423 | + | 219 | Protein_3832 | hypothetical protein | - |
| FYA15_RS24035 | 4008461..4008577 | + | 117 | Protein_3833 | VOC family protein | - |
| FYA15_RS19655 | 4008822..4009943 | + | 1122 | WP_000010829.1 | M42 family metallopeptidase | - |
| FYA15_RS19660 | 4009940..4010218 | + | 279 | WP_000722973.1 | PTS sugar transporter subunit IIB | - |
| FYA15_RS19665 | 4010230..4011543 | + | 1314 | WP_000460843.1 | galactitol-specific PTS transporter subunit IIC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | fimB | 3997671..4015458 | 17787 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 9734.29 Da Isoelectric Point: 11.0090
>T137550 WP_001054376.1 NZ_CP043191:4006420-4006677 [Escherichia coli O16:H48]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR
Download Length: 258 bp
>T137550 NZ_CP056780:c30687-30271 [Enterobacter cloacae]
GTGAACAAGATCTATATGCTCGATACCAACATCTGCTCTTTCATCATGCGCGAGCAGCCGGAAGCCGTGCTGAAGCGCCT
GGAGCAGGCTGTGCTGCGCGGTCACCGCATCGTGGTCTCGGCCATCACCTACTCGGAGATGCGCTTCGGGGCCACCGGAC
CGAAGGCTTCCCCCCGACACGTGCAGCTGGTTGACGCCTTCTGCACCCGCCTCGATGCCATCCTGCCCTGGGACCGCGCC
GCGGTGGATGCGACTACAGAAATCAAGGTCGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGATACGGCGATTGC
CGGGCACGCCATTGCCGCCGGCGCCGTGCTGGTGACTAACAATGTGCGGGAGTTTGAGCGGGTGCCGGGCCTGACGCTTG
AAGACTGGGTTAACTGA
GTGAACAAGATCTATATGCTCGATACCAACATCTGCTCTTTCATCATGCGCGAGCAGCCGGAAGCCGTGCTGAAGCGCCT
GGAGCAGGCTGTGCTGCGCGGTCACCGCATCGTGGTCTCGGCCATCACCTACTCGGAGATGCGCTTCGGGGCCACCGGAC
CGAAGGCTTCCCCCCGACACGTGCAGCTGGTTGACGCCTTCTGCACCCGCCTCGATGCCATCCTGCCCTGGGACCGCGCC
GCGGTGGATGCGACTACAGAAATCAAGGTCGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGATACGGCGATTGC
CGGGCACGCCATTGCCGCCGGCGCCGTGCTGGTGACTAACAATGTGCGGGAGTTTGAGCGGGTGCCGGGCCTGACGCTTG
AAGACTGGGTTAACTGA
Antitoxin
Download Length: 182 a.a. Molecular weight: 19956.90 Da Isoelectric Point: 6.3277
>AT137550 WP_001309181.1 NZ_CP043191:4006689-4007234 [Escherichia coli O16:H48]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT
Download Length: 546 bp
>AT137550 NZ_CP043191:4006689-4007234 [Escherichia coli O16:H48]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|