Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4091428..4092023 Replicon chromosome
Accession NZ_CP043187
Organism Escherichia coli O16:H48 strain PG20180170

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag FYA17_RS20055 Protein ID WP_000239577.1
Coordinates 4091428..4091778 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag FYA17_RS20060 Protein ID WP_001223208.1
Coordinates 4091772..4092023 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA17_RS20035 4086874..4087896 - 1023 WP_001313531.1 ABC transporter permease -
FYA17_RS20040 4087910..4089412 - 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
FYA17_RS20045 4089552..4090508 - 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
FYA17_RS20050 4090818..4091348 + 531 WP_000055075.1 inorganic diphosphatase -
FYA17_RS20055 4091428..4091778 - 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
FYA17_RS20060 4091772..4092023 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
FYA17_RS20065 4092235..4092576 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
FYA17_RS20070 4092579..4096358 - 3780 WP_000060911.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T137488 WP_000239577.1 NZ_CP043187:c4091778-4091428 [Escherichia coli O16:H48]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T137488 NZ_CP043187:c4091778-4091428 [Escherichia coli O16:H48]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT137488 WP_001223208.1 NZ_CP043187:c4092023-4091772 [Escherichia coli O16:H48]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT137488 NZ_CP056752:49060-49290 [Enterobacter hormaechei]
ATGCGCACAGTATCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTAG
ACAGGGCCGATCCGGACTTTATGGCGCAGCGTGAGGATGTGGTCAGCGACGAAGGACGCTTTGATCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References