137487

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4006417..4007231 Replicon chromosome
Accession NZ_CP043187
Organism Escherichia coli O16:H48 strain PG20180170

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag FYA17_RS19635 Protein ID WP_001054376.1
Coordinates 4006417..4006674 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag FYA17_RS19640 Protein ID WP_001309181.1
Coordinates 4006686..4007231 (+) Length 182 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA17_RS19615 4001705..4002811 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
FYA17_RS19620 4002876..4003856 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
FYA17_RS19625 4004439..4005679 - 1241 Protein_3826 helicase YjhR -
FYA17_RS19630 4005795..4006040 + 246 Protein_3827 GNAT family N-acetyltransferase -
FYA17_RS19635 4006417..4006674 + 258 WP_001054376.1 hypothetical protein Toxin
FYA17_RS19640 4006686..4007231 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
FYA17_RS19645 4007287..4008033 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
FYA17_RS19650 4008202..4008420 + 219 Protein_3831 hypothetical protein -
FYA17_RS23215 4008458..4008574 + 117 Protein_3832 VOC family protein -
FYA17_RS19655 4008819..4009940 + 1122 WP_000010829.1 M42 family metallopeptidase -
FYA17_RS19660 4009937..4010215 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
FYA17_RS19665 4010227..4011540 + 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 3997668..4015455 17787


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-85)

Antitoxin

(18-121)


Sequences


Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T137487 WP_001054376.1 NZ_CP043187:4006417-4006674 [Escherichia coli O16:H48]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T137487 NZ_CP043187:4006417-4006674 [Escherichia coli O16:H48]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT137487 WP_001309181.1 NZ_CP043187:4006686-4007231 [Escherichia coli O16:H48]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT137487 NZ_CP056751:c4690181-4689939 [Enterobacter hormaechei]
ATGAGCGTTTTGGCGGAACTTGATATGGGCAGAATACTTATCGATTTGTCTGATGACGTGATTCAACGTTTGGATAACCT
CAAGCAATTGCGAAATCAACCACGTGCTGAACTGCTTCGGGAAGCGATAGAACTGTATCTCGACCAGCAGAGTTCTTCTG
TTATCCGAAATGCGCTTGGTCTGTGGGGAGACAGAAAAGAGGACGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1PA82


Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References