137448

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3263786..3264600 Replicon chromosome
Accession NZ_CP043185
Organism Escherichia coli O16:H48 strain PG20180171

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag FYA18_RS15760 Protein ID WP_001054376.1
Coordinates 3264343..3264600 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag FYA18_RS15755 Protein ID WP_001309181.1
Coordinates 3263786..3264331 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA18_RS15730 3259477..3260790 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
FYA18_RS15735 3260802..3261080 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
FYA18_RS15740 3261077..3262198 - 1122 WP_000010829.1 M42 family metallopeptidase -
FYA18_RS22835 3262443..3262559 - 117 Protein_3054 VOC family protein -
FYA18_RS15745 3262597..3262815 - 219 Protein_3055 hypothetical protein -
FYA18_RS15750 3262984..3263730 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
FYA18_RS15755 3263786..3264331 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
FYA18_RS15760 3264343..3264600 - 258 WP_001054376.1 hypothetical protein Toxin
FYA18_RS15765 3264977..3265222 - 246 Protein_3059 GNAT family N-acetyltransferase -
FYA18_RS15770 3265338..3266578 + 1241 Protein_3060 helicase YjhR -
FYA18_RS15775 3267161..3268141 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
FYA18_RS15780 3268206..3269312 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T137448 WP_001054376.1 NZ_CP043185:c3264600-3264343 [Escherichia coli O16:H48]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T137448 NZ_CP043185:c3264600-3264343 [Escherichia coli O16:H48]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT137448 WP_001309181.1 NZ_CP043185:c3264331-3263786 [Escherichia coli O16:H48]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT137448 NZ_CP056742:c2994022-2993753 [Enterobacter hormaechei]
ATGCCAGCACTCAAAAAACAGCGTATCGATCTTCGCCTGTCGGACGAAGACAAAACAATGATTGAAGAAGCGGCAGCGAT
GACCAACCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGTGCTGCCGAAGTCATCGAACAGCATCGGCGTC
TCGTATTAAACGAAGCCTCATGGAATGCCGTTATGGATGCCATCGACAATCCGCCAGAGCCAAATGAACGCCTGAAGCGA
GCGGCGAAACGTCTTCGAAACATGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References