Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3445833..3446383 Replicon chromosome
Accession NZ_CP043181
Organism Escherichia coli O2:H6 strain PG20180057

Toxin (Protein)


Gene name ccdB Uniprot ID S1PDG4
Locus tag FYA20_RS16695 Protein ID WP_001160966.1
Coordinates 3446069..3446383 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag FYA20_RS16690 Protein ID WP_000125566.1
Coordinates 3445833..3446066 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11711.72 Da        Isoelectric Point: 9.0851

>T137381 WP_001160966.1 NZ_CP043181:3446069-3446383 [Escherichia coli O2:H6]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

>T137381 NZ_CP056711:3748363-3748659 [Enterobacter asburiae]
GTGCCGGTTTCGTCACGCCTGTCGCCCGTAATGGTGTGGCAGCAGTTGTTAACGTATCTGCTGGAGCACCACTACGGCCT
CACACTCAACGACACACCATTTCATGACGACACGGCCATTGAGGAGCATATCGATGCGGGGATAACGCTTGCCGATGCTG
TTAATTTCCTGGTCGAAAAGTACGAACTGGCTCGTATCGACCGCAAGGGATTTACATGGCGAGAGCAACCCCCCTTCATT
ACTGCAACGGATATTCTGCGTGCCAAAAAGAACATCGGGCTGTTGCCCAGATCTTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT137381 WP_000125566.1 NZ_CP043181:3445833-3446066 [Escherichia coli O2:H6]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT137381 NZ_CP043181:3445833-3446066 [Escherichia coli O2:H6]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G815

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References