Detailed information of TA system TA137376

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 2918460..2919448
• Replicon: chromosome
• Accession: NZ_CP043181
• Organism: Escherichia coli O2:H6 strain PG20180057

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: FYA20_RS14040
• Protein ID: WP_014640052.1
• Coordinates: 2919062..2919448 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: FYA20_RS14035
• Protein ID: WP_021538830.1
• Coordinates: 2918460..2919032 (+)
• Length: 191 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYA20_RS14010	2914620..2914988	+	369	WP_000002907.1	diacylglycerol kinase	-
FYA20_RS14015	2915098..2915706	+	609	WP_000646078.1	transcriptional repressor LexA	-
FYA20_RS14020	2915779..2917104	+	1326	WP_001350407.1	MATE family efflux transporter DinF	-
FYA20_RS14025	2917220..2917429	+	210	WP_001296638.1	CsbD family protein	-
FYA20_RS14030	2917471..2917986	-	516	WP_000416264.1	zinc uptake transcriptional repressor Zur	-
FYA20_RS14035	2918460..2919032	+	573	WP_021538830.1	SocA family protein	Antitoxin
FYA20_RS14040	2919062..2919448	+	387	WP_014640052.1	hypothetical protein	Toxin
FYA20_RS25165	2919488..2919661	+	174	WP_021538831.1	hypothetical protein	-
FYA20_RS14045	2919709..2919990	-	282	WP_001093916.1	pyocin activator PrtN family protein	-
FYA20_RS14050	2920027..2920599	-	573	WP_023145273.1	3'-5' exoribonuclease	-
FYA20_RS14055	2920599..2921339	-	741	WP_023145274.1	hypothetical protein	-
FYA20_RS14060	2921343..2921630	-	288	WP_000212745.1	hypothetical protein	-
FYA20_RS14065	2921632..2922417	-	786	WP_021529121.1	ead/Ea22-like family protein	-
FYA20_RS14070	2922404..2922652	-	249	WP_000476209.1	hypothetical protein	-
FYA20_RS14075	2922645..2922848	-	204	WP_000111289.1	hypothetical protein	-
FYA20_RS14080	2922845..2923207	-	363	WP_001242718.1	phage protein	-
FYA20_RS14085	2923198..2923734	-	537	WP_000008177.1	5'-deoxynucleotidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2915098..2965746	50648

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (27-137)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14465.40 Da
• Isoelectric Point: 5.4833

>T137376 WP_014640052.1 NZ_CP043181:2919062-2919448 [Escherichia coli O2:H6]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Nucleotide

• Length: 387 bp

>T137376 NZ_CP056711:569454-569738 [Enterobacter asburiae]
ATGACTTATGAACTGGCATTTGACCCGAGGGCGTTAAAGGAGTGGTGCAAGCTGGGGCAGACTGTAAAAGACCTGTTTAA
GAAGAAACTTGCGGACGTGCTGGTGAACCCCAGGGTCGAATCGGCCCGCCTGCATGGTCTGCCGGATTGCTACAAAATAA
AACTCAGAACGCAGGGTTATCGTTTGGTCTATCAGGTTCAGGACAACGTTGTAACGGTATTTGTTATCGCTATCGGTAAG
CGAGAGAAATCAGCTGTTTATCATGATGCAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 191 a.a.
• Molecular weight: 21987.31 Da
• Isoelectric Point: 5.6404

>AT137376 WP_021538830.1 NZ_CP043181:2918460-2919032 [Escherichia coli O2:H6]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHDVLLRSDPREMDADEVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHDPGYSRKPIDLKEMLI
SEGKSEDEANHIIGKMEESQKLKEFSLQLS

Nucleotide

• Length: 573 bp

>AT137376 NZ_CP056711:569222-569464 [Enterobacter asburiae]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAACGAGGCTTATGCCGTGCTGGAAAAACTCAATATCACCCC
AACGGAAGCCGTGCGATTACTGTTTCAGTACGTCGCGGAGACGGGACGTATGCCGGTGAAAACGGTCACGATTAGCGACA
GCGAAGATGCGCTGATACAGACGGTCCGGGAGCGACTGGCGAATCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA