Detailed information of TA system TA137360

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 340458..341099
• Replicon: chromosome
• Accession: NZ_CP043180
• Organism: Acinetobacter baumannii strain PG20180064

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A5N0FZY3
• Locus tag: FYA21_RS01640
• Protein ID: WP_000607074.1
• Coordinates: 340458..340847 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: FYA21_RS01645
• Protein ID: WP_011860336.1
• Coordinates: 340854..341099 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYA21_RS01625	335576..337771	-	2196	WP_096641083.1	TRAP transporter large permease subunit	-
FYA21_RS01630	337959..338525	-	567	WP_000651536.1	rhombosortase	-
FYA21_RS01635	338603..339688	-	1086	WP_000049106.1	hypothetical protein	-
FYA21_RS01640	340458..340847	-	390	WP_000607074.1	membrane protein	Toxin
FYA21_RS01645	340854..341099	-	246	WP_011860336.1	succinate dehydrogenase assembly factor 2	Antitoxin
FYA21_RS01650	341299..342471	+	1173	WP_001190547.1	acyl-CoA dehydrogenase family protein	-
FYA21_RS01655	342520..344010	-	1491	WP_096641081.1	NAD(P)/FAD-dependent oxidoreductase	-
FYA21_RS01660	344192..344569	-	378	WP_001216380.1	50S ribosomal protein L17	-
FYA21_RS01665	344588..345595	-	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (6-78)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15621.89 Da
• Isoelectric Point: 10.3890

>T137360 WP_000607074.1 NZ_CP043180:c340847-340458 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKVIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T137360 NZ_CP043180:c340847-340458 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAGTAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9842.27 Da
• Isoelectric Point: 4.9001

>AT137360 WP_011860336.1 NZ_CP043180:c341099-340854 [Acinetobacter baumannii]
MTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLKHYVH
G

Nucleotide

• Length: 246 bp

>AT137360 NZ_CP056707:c97578-97279 [Enterobacter hormaechei]
GTGAAAACCTTAAATGAAGTGATTGCGTCACGCTCACCGGAAAGCCAACAGCGCATTCAGGAGATGGCAGAGGAAATGTT
CCTCGAAACCGGTCTGCAACTTCTGCGTGAAGAGCTCCAGCTTTCGCAAAAACATGTCGCCGATCTTATGGGCGTAAGTC
AACCTGCGGTAACACAGCTGGAGCAGCGTGGAAACGATCTTAAGATTGCTACGCTTAAGCGTTACATCGAAGCGATGGGC
GGAAAACTTAGCATTAACGTGGAACTTCCCACTGGCAAGCGGGTTGCGTTTCATCTCTAG

Structures

Toxin

• AlphaFold DB: A0A5N0FZY3