Detailed information of TA system TA137359

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 6501419..6502695
• Replicon: chromosome
• Accession: NZ_CP043179
• Organism: Pseudomonas protegens strain SN15-2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q4KD87
• Locus tag: FQ342_RS29165
• Protein ID: WP_011060985.1
• Coordinates: 6501419..6502018 (-)
• Length: 200 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FQ342_RS29170
• Protein ID: WP_011060984.1
• Coordinates: 6502138..6502695 (-)
• Length: 186 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FQ342_RS29145	6497221..6497649	+	429	WP_011060989.1	hypothetical protein	-
FQ342_RS29150	6497697..6498317	+	621	WP_011060988.1	hypothetical protein	-
FQ342_RS29155	6498277..6498963	+	687	WP_011060987.1	hypothetical protein	-
FQ342_RS29160	6499025..6501205	-	2181	WP_011060986.1	catalase/peroxidase HPI	-
FQ342_RS29165	6501419..6502018	-	600	WP_011060985.1	HD domain-containing protein	Toxin
FQ342_RS29170	6502138..6502695	-	558	WP_011060984.1	helix-turn-helix domain-containing protein	Antitoxin
FQ342_RS29175	6502885..6503226	+	342	WP_011060983.1	low molecular weight protein tyrosine phosphatase family protein	-
FQ342_RS29180	6503264..6503674	+	411	WP_041774583.1	hypothetical protein	-
FQ342_RS29185	6503853..6505040	-	1188	WP_011060981.1	hypothetical protein	-
FQ342_RS29190	6505500..6506087	+	588	WP_011060980.1	inclusion body family protein	-
FQ342_RS29195	6506133..6506753	-	621	WP_011060979.1	LysE family translocator	-
FQ342_RS29200	6506841..6507491	-	651	WP_011060978.1	DUF2239 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (8-193)

Antitoxin

• Cro/C1-type helix-turn-helix domain (15-48)

Sequences

Toxin

Protein

• Length: 200 a.a.
• Molecular weight: 22413.22 Da
• Isoelectric Point: 5.8382

>T137359 WP_011060985.1 NZ_CP043179:c6502018-6501419 [Pseudomonas protegens]
MNSELLSGRLEFLREAEKLKDVLRSAHTSSGRQESTAEHSWRLCLMALLFEDQLGDLDLLRVLKLCIVHDLGEAIHGDIP
AVAQAAHPDKSPQERADLQLLARALDAPAREHLLELWDEYEGAASNEARAVKALDKLETLLQHTQGQNPAGFDYRFNLGY
GRRYTDASPLFQALRQQIDADTQRRLDAQAQAAVQHRLR

Nucleotide

• Length: 600 bp

>T137359 NZ_CP043179:c6502018-6501419 [Pseudomonas protegens]
ATGAACAGTGAACTTCTCAGTGGCCGCCTTGAATTCCTCCGTGAAGCGGAAAAACTCAAGGACGTGCTGCGCAGTGCCCA
CACCTCCAGCGGCCGCCAGGAAAGCACCGCCGAGCACAGCTGGCGCCTGTGCCTGATGGCGCTGCTGTTCGAAGACCAAC
TGGGGGATCTGGACCTACTGCGGGTGCTGAAGCTGTGCATCGTTCACGACCTGGGGGAGGCCATTCACGGCGATATCCCG
GCGGTGGCCCAGGCCGCCCACCCGGACAAGAGCCCGCAGGAGCGCGCGGACCTGCAACTGCTGGCCCGAGCCCTGGACGC
CCCGGCCCGCGAGCACCTGCTGGAGCTGTGGGACGAATACGAAGGCGCCGCCAGCAACGAGGCGCGCGCGGTCAAGGCCC
TGGACAAGCTGGAAACCCTGCTGCAACACACCCAGGGCCAGAACCCGGCGGGTTTCGACTACCGCTTCAACCTCGGCTAC
GGCCGCCGCTACACCGATGCCAGCCCGCTGTTCCAGGCCCTGCGCCAGCAGATCGATGCCGACACCCAGCGCCGCCTGGA
CGCCCAGGCTCAGGCCGCGGTTCAGCATCGGCTGCGCTAA

Antitoxin

Protein

• Length: 186 a.a.
• Molecular weight: 20446.44 Da
• Isoelectric Point: 7.4189

>AT137359 WP_011060984.1 NZ_CP043179:c6502695-6502138 [Pseudomonas protegens]
MSVALFTSPHLGLALRRWRLLHRVKQQHAAELFGVAQSSISRWENGRQAMEPAERARLEQLLAANLSAAADQALARLVHD
SPRAVHLVCDLTHRLLACSVTRAGQFGVPLSELLGQSLWGFCTEEIVRKEAALDDLGWREVLAPPSLEFFSGHNDSAIVP
IAPSQCRWTRLNLSDGNAVRLVETL

Nucleotide

• Length: 558 bp

>AT137359 NZ_CP056707:82911-83162 [Enterobacter hormaechei]
ATGCGTGTTATTAGTTACAGTGAAGCCCGACAAAACCTGTCGGCAACCATGGTTCAGACGACGGAAGACCGCGCGCCGGT
GCTTATTACGCGCCAGAACGGTGAATCTTGTGTTCTGATGTCGCTGGAAGAGTACAACTCGCTTGAAGAAACCGCATACC
TGATGCGCTCCCCGGCAAACGCAAAACGTCTGATGAACTCTATCGAGAGCTTGAAATCTGGTAGCGGGAAGGAAAGGGAC
ATTATTGAGTGA

Structures

Toxin

• AlphaFold DB: Q4KD87