Detailed information of TA system TA137357

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2211129..2211645
• Replicon: chromosome
• Accession: NZ_CP043179
• Organism: Pseudomonas protegens strain SN15-2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F9XXF1
• Locus tag: FQ342_RS10200
• Protein ID: WP_011058535.1
• Coordinates: 2211129..2211410 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q4KKD3
• Locus tag: FQ342_RS10205
• Protein ID: WP_011058534.1
• Coordinates: 2211400..2211645 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FQ342_RS10180	2207381..2208271	-	891	WP_011058539.1	HlyD family secretion protein	-
FQ342_RS10185	2208268..2208477	-	210	WP_011058538.1	DUF1656 domain-containing protein	-
FQ342_RS10190	2208474..2210561	-	2088	WP_011058537.1	FUSC family protein	-
FQ342_RS10195	2210558..2210986	-	429	WP_011058536.1	winged helix DNA-binding protein	-
FQ342_RS10200	2211129..2211410	-	282	WP_011058535.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FQ342_RS10205	2211400..2211645	-	246	WP_011058534.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FQ342_RS10210	2211710..2211955	-	246	WP_011058533.1	DUF2789 domain-containing protein	-
FQ342_RS10215	2211970..2212431	-	462	WP_011058532.1	YbaK/EbsC family protein	-
FQ342_RS10220	2212541..2214151	-	1611	WP_011058531.1	glycosyltransferase family 39 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-69)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10839.72 Da
• Isoelectric Point: 10.2298

>T137357 WP_011058535.1 NZ_CP043179:c2211410-2211129 [Pseudomonas protegens]
MTYSLEFLPSAHKEWNKLGHTLREQFKKKLAERLEVPRIPADALHGLPDCYKIKLKASGYRLVYQVIEERVVVCVVAVGK
RERGTVYEQARKR

Nucleotide

• Length: 282 bp

>T137357 NZ_CP056707:60276-60668 [Enterobacter hormaechei]
ATGCTGCATATGCTGGACACTAACATCGTAAGCCATCTGGTGAGGCAGCATCCTGAAGTTGTAAACCGATATTCGCAAAT
TACGCCTGAAAAGATGTGTATTTCAAGCGTAACGGAAGCGGAATTGCTTTACGGCGTAGCCAAAAAGCAAAACAACAAGC
TGCACGAAACCATAATGGAATTTCTTAAAACCATCACTGTCTGCGCCTGGGATAGCGAAGCCGCAGCCATCTACGGTGAA
CTGCGTGCGGCAATGGAAAAGAAAGGGAAAGTGATGGGGGATCTCGATCAGTTGATTGCCGCACATGCTATCAGCCGGGG
CACGACGATTGTCACGAACGATCATGCGTTCGGGATGGTACAGGATCTTACGGTTGAGGACTGGACTCAATAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8799.10 Da
• Isoelectric Point: 4.3988

>AT137357 WP_011058534.1 NZ_CP043179:c2211645-2211400 [Pseudomonas protegens]
MQSILADKAVSVSELKKNPSAVLSGAQGGPVAVLNHNRVMGYMVPAEVFEALMERLDDLELAEIIRERSHETPVPVSLDD
L

Nucleotide

• Length: 246 bp

>AT137357 NZ_CP056707:60012-60272 [Enterobacter hormaechei]
ATGGAACGCACAGCGAAACTATTCAAAAAAGGACGAAACCAGGCCGTGGTCTTGCCTGCGGAATTTGCGTTTGAAACGGA
GAGTGTTTATATCCGCCGGGATGACGAGGGGAATGTGGTTTTGACGGCAAGGTCCGAGAAAGCACGGCACAGGGATAACT
TTTTGCGCATGTTAAAAGAAACGCATGTGCCTGATACCTTTCTAAGTAAAGAGGAGCGCAATCAGAGCTATACGACAAGA
AACCCTCTTGAAGGGCTGTAG

Structures

Toxin

• AlphaFold DB: F9XXF1

Antitoxin

• AlphaFold DB: Q4KKD3