Detailed information of TA system TA137342

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpA-brnA/BrnT_toxin-BrnA
• Location: 2091521..2092052
• Replicon: chromosome
• Accession: NZ_CP043163
• Organism: Bordetella parapertussis strain H102

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: K0MH61
• Locus tag: FYA51_RS09980
• Protein ID: WP_003812626.1
• Coordinates: 2091786..2092052 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: K0MF02
• Locus tag: FYA51_RS09975
• Protein ID: WP_003816743.1
• Coordinates: 2091521..2091799 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYA51_RS09945	2086952..2088046	+	1095	WP_003812637.1	TRAP transporter substrate-binding protein	-
FYA51_RS09950	2088258..2088886	+	629	Protein_1954	TRAP transporter small permease subunit	-
FYA51_RS09955	2088889..2090556	+	1668	WP_010928294.1	TRAP transporter large permease subunit	-
FYA51_RS09960	2090571..2091227	+	657	WP_010928295.1	phosphoribosylanthranilate isomerase	-
FYA51_RS09975	2091521..2091799	-	279	WP_003816743.1	BrnA antitoxin family protein	Antitoxin
FYA51_RS09980	2091786..2092052	-	267	WP_003812626.1	BrnT family toxin	Toxin
FYA51_RS09985	2092283..2093824	-	1542	WP_010928296.1	M81 family metallopeptidase	-
FYA51_RS09990	2093886..2094764	-	879	WP_041937387.1	tripartite tricarboxylate transporter substrate binding protein	-
FYA51_RS09995	2095161..2095793	+	633	WP_003812619.1	PAS domain-containing protein	-
FYA51_RS10000	2095904..2096614	+	711	WP_003812617.1	aquaporin Z	-
FYA51_RS10005	2096653..2096925	-	273	WP_003812615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-81)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (12-86)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10037.47 Da
• Isoelectric Point: 7.9923

>T137342 WP_003812626.1 NZ_CP043163:c2092052-2091786 [Bordetella parapertussis]
MDITYDPAKNDKNIADRGLSFELVCGFEWASALVVEDTRQVYAETRYQALGKIDGRLHMVVFTVRGESLRIISLRKANAR
EVARYEKA

Nucleotide

• Length: 267 bp

>T137342 NZ_CP056698:56905-57303 [Escherichia marmotae]
ATGCTGAAATTCATGCTGGACACGAATATCTGTATCTTCACGATTAAGAACAAACCGGCGCATATTCGGGAACGATTCAA
CCTGAACTCAGGGCGAATGTGCATCAGCTCAGTTACCGTGATGGAGCTGGTATACGGCGCTGAAAAAAGTCAGTTTCCGG
AGCGTAATCTCGCGATTATAGAAGGATTTATTTCGCGCCTTGACGTGCTGGATTACGACTGCGCTGCTGCCACACATACC
GGTCAGATCCGTGCTGAGCTCGCCCGTCAGGGACGTCCGGTGGGACCGTTTGATCAGATGATTGCCGGTCATGCCCGTAG
CCGGGGACTCATTGTGGTCACAAACAATACCCGGGAGTTTGAACGTATCTCCGGCCTTCGTCTGGAAGACTGGTGTTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10412.89 Da
• Isoelectric Point: 10.5548

>AT137342 WP_003816743.1 NZ_CP043163:c2091799-2091521 [Bordetella parapertussis]
MKKPDPEKIDRDNPEWTDAEFRRAKPAAEVLPESVHAMLGIRRRGPQKTPTKQVVTIRLSPDVVEAFKASGTGWQTRVDA
ALRDWLKTHQPG

Nucleotide

• Length: 279 bp

>AT137342 NZ_CP056698:56678-56905 [Escherichia marmotae]
ATGGAAACGACCGTATTTCTCAGTAACCGGAGTCAGGCAGTCAGGCTGCCGAAAGCTGTAGCCCTGCCTGAAGACGTAAA
AAAAGTCGACGTTATTGCTGTTGGCCGTACCCGGATCATTACCCCGGCAGGAGAGTCCTGGGACAGCTGGTTCGATGGCG
ACAGTGTCAGCGCAGATTTCATGAATGACAGAGAACAACCCGCCGTACAGGAAAGGGAGTCGTTCTGA

Structures

Toxin

• AlphaFold DB: K0MH61

Antitoxin

• AlphaFold DB: K0MF02