Detailed information of TA system TA137340

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3381720..3382356
• Replicon: chromosome
• Accession: NZ_CP043162
• Organism: Bordetella parapertussis strain H104

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q7W5Z1
• Locus tag: FYA53_RS15985
• Protein ID: WP_010928914.1
• Coordinates: 3381720..3381902 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q7W5Z0
• Locus tag: FYA53_RS15990
• Protein ID: WP_010928915.1
• Coordinates: 3381964..3382356 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYA53_RS15960	3377294..3377971	+	678	WP_010928910.1	HAD-IA family hydrolase	-
FYA53_RS15965	3378189..3379376	+	1188	WP_010928911.1	MFS transporter	-
FYA53_RS15975	3379951..3381171	+	1221	WP_010928912.1	ISL3-like element IS1001 family transposase	-
FYA53_RS15985	3381720..3381902	+	183	WP_010928914.1	type II toxin-antitoxin system HicA family toxin	Toxin
FYA53_RS15990	3381964..3382356	+	393	WP_010928915.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FYA53_RS15995	3382629..3383538	-	910	Protein_3139	LysR family transcriptional regulator	-
FYA53_RS16000	3383663..3384637	+	975	WP_010928916.1	tripartite tricarboxylate transporter substrate binding protein	-
FYA53_RS16005	3384672..3385031	+	360	WP_010928917.1	hypothetical protein	-
FYA53_RS16010	3385098..3386270	+	1173	WP_010928918.1	thiolase domain-containing protein	-
FYA53_RS16015	3386274..3386700	+	427	Protein_3143	OB-fold domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3379951..3381171	1220

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6572.69 Da
• Isoelectric Point: 10.9062

>T137340 WP_010928914.1 NZ_CP043162:3381720-3381902 [Bordetella parapertussis]
MDGKELIKQLERSGWTLRSVKGSHHVFAHPDRPGHISVPHPKKDLGIGLLNSILKAAGLK

Nucleotide

• Length: 183 bp

>T137340 NZ_CP056698:c44620-44138 [Escherichia marmotae]
ATGGAAATAAATGTCACCGCGCCGGCATTGCTGACAGATGAGCATATACTTCAGCCATTTGACTGTGGGAATGAGGTGTT
AAGTAACTGGTTGCGTGGTCGGGCTATGAAAAACCAGATGCTCAATGCTTCCCGCACGTTCGTCATTTGTCTGGAGGATA
CTTTACGTGTTGTGGGGTATTACTCATTAGCTACTGGTTCTGTCACACATGCCGAGCTTGGGCGCAGTTTGCGCCATAAT
ATGCCCAATCCTGTACCTGTTGTTCTTTTAGGGCGTCTGGCTGTCGATGTTTGTACTCAGGGACATGGTTTCGGTAAATG
GCTGCTGAGTGATGCCATTCATCGGGTTGCCAATTTGGCTGAACAGGTTGGCATTAAGGCTGTTATGGTTCATGCAATTG
ATGATGACGCCAGAGTTTTTTATGAGCATTTTGGTTTTGTTCAGTCAGTTGTGGCACCTGATACCTTGTTTTATAAAATT
TGA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 14058.82 Da
• Isoelectric Point: 4.2876

>AT137340 WP_010928915.1 NZ_CP043162:3381964-3382356 [Bordetella parapertussis]
VKYPIAIEPGSDTRAWGVVVPDLPGCFSAADEGIDQAIENAKEAIELWIETAIDSGAPIPAATNIANHQANPEFANWIWA
IADVDPAVLDETVERVNITIPRRILKRLDDRARAAGESRSSYIAHLAMTA

Nucleotide

• Length: 393 bp

>AT137340 NZ_CP043162:3381964-3382356 [Bordetella parapertussis]
GTGAAATATCCCATTGCCATTGAACCCGGCAGCGACACGCGCGCCTGGGGAGTCGTTGTTCCTGATCTGCCCGGCTGCTT
TTCCGCAGCGGACGAAGGGATTGATCAAGCAATCGAGAACGCCAAGGAAGCCATTGAGTTGTGGATTGAAACGGCCATCG
ACTCCGGCGCCCCCATTCCTGCGGCAACCAACATAGCCAATCATCAGGCCAATCCTGAGTTCGCCAACTGGATTTGGGCG
ATTGCTGATGTCGATCCTGCAGTCTTGGATGAAACTGTCGAGCGCGTGAACATCACAATCCCGCGCCGAATTCTCAAGCG
CCTGGATGATCGCGCCCGCGCCGCCGGCGAAAGCCGGAGCAGCTACATCGCACATCTCGCCATGACTGCCTGA

Structures

Toxin

• AlphaFold DB: Q7W5Z1

Antitoxin

• AlphaFold DB: Q7W5Z0