Detailed information of TA system TA137337

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpA-brnA/BrnT_toxin-BrnA
• Location: 2091496..2092027
• Replicon: chromosome
• Accession: NZ_CP043162
• Organism: Bordetella parapertussis strain H104

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: K0MH61
• Locus tag: FYA53_RS09985
• Protein ID: WP_003812626.1
• Coordinates: 2091761..2092027 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: K0MF02
• Locus tag: FYA53_RS09980
• Protein ID: WP_003816743.1
• Coordinates: 2091496..2091774 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYA53_RS09950	2086927..2088021	+	1095	WP_003812637.1	TRAP transporter substrate-binding protein	-
FYA53_RS09955	2088233..2088862	+	630	WP_010928293.1	TRAP transporter small permease subunit	-
FYA53_RS09960	2088865..2090531	+	1667	Protein_1955	TRAP transporter large permease subunit	-
FYA53_RS09965	2090546..2091202	+	657	WP_010928295.1	phosphoribosylanthranilate isomerase	-
FYA53_RS09980	2091496..2091774	-	279	WP_003816743.1	BrnA antitoxin family protein	Antitoxin
FYA53_RS09985	2091761..2092027	-	267	WP_003812626.1	BrnT family toxin	Toxin
FYA53_RS09990	2092258..2093799	-	1542	WP_010928296.1	M81 family metallopeptidase	-
FYA53_RS09995	2093861..2094739	-	879	WP_041937387.1	tripartite tricarboxylate transporter substrate binding protein	-
FYA53_RS10000	2095136..2095768	+	633	WP_003812619.1	PAS domain-containing protein	-
FYA53_RS10005	2095879..2096589	+	711	WP_003812617.1	aquaporin Z	-
FYA53_RS10010	2096628..2096900	-	273	WP_003812615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-81)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (12-86)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10037.47 Da
• Isoelectric Point: 7.9923

>T137337 WP_003812626.1 NZ_CP043162:c2092027-2091761 [Bordetella parapertussis]
MDITYDPAKNDKNIADRGLSFELVCGFEWASALVVEDTRQVYAETRYQALGKIDGRLHMVVFTVRGESLRIISLRKANAR
EVARYEKA

Nucleotide

• Length: 267 bp

>T137337 NZ_CP043162:c2092027-2091761 [Bordetella parapertussis]
ATGGATATCACCTACGACCCCGCCAAGAACGACAAGAACATTGCCGATCGCGGCCTGTCGTTCGAGTTGGTGTGTGGCTT
CGAGTGGGCCAGCGCGCTGGTGGTTGAGGATACCCGCCAGGTCTACGCCGAAACGCGCTATCAGGCGCTGGGCAAAATCG
ATGGCCGGCTCCATATGGTGGTATTCACGGTGCGCGGCGAGTCGCTGCGCATCATCAGCCTGCGTAAGGCAAATGCTCGT
GAGGTAGCTCGTTATGAAAAAGCCTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10412.89 Da
• Isoelectric Point: 10.5548

>AT137337 WP_003816743.1 NZ_CP043162:c2091774-2091496 [Bordetella parapertussis]
MKKPDPEKIDRDNPEWTDAEFRRAKPAAEVLPESVHAMLGIRRRGPQKTPTKQVVTIRLSPDVVEAFKASGTGWQTRVDA
ALRDWLKTHQPG

Nucleotide

• Length: 279 bp

>AT137337 NZ_CP056697:c4729608-4729240 [Escherichia marmotae]
GTGTCAGACACTCTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Structures

Toxin

• AlphaFold DB: K0MH61

Antitoxin

• AlphaFold DB: K0MF02