Detailed information of TA system TA137333

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2225656..2226250
• Replicon: chromosome
• Accession: NZ_CP043161
• Organism: Bordetella parapertussis strain H105

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: K0M8J0
• Locus tag: FYA54_RS10620
• Protein ID: WP_010928352.1
• Coordinates: 2226068..2226250 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: K0MFV7
• Locus tag: FYA54_RS10615
• Protein ID: WP_010928351.1
• Coordinates: 2225656..2226045 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYA54_RS10590	2221499..2222539	+	1041	WP_003809635.1	phosphate ABC transporter substrate-binding protein PstS	-
FYA54_RS10595	2222674..2223690	+	1017	WP_010928350.1	phosphate ABC transporter permease subunit PstC	-
FYA54_RS10600	2223712..2224569	+	858	WP_003809638.1	phosphate ABC transporter permease PstA	-
FYA54_RS10605	2224614..2225390	+	777	WP_033448479.1	phosphate ABC transporter ATP-binding protein PstB	-
FYA54_RS10615	2225656..2226045	-	390	WP_010928351.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FYA54_RS10620	2226068..2226250	-	183	WP_010928352.1	type II toxin-antitoxin system HicA family toxin	Toxin
FYA54_RS10625	2226658..2227356	+	699	WP_003809653.1	gluconate 2-dehydrogenase subunit 3 family protein	-
FYA54_RS10630	2227360..2229129	+	1770	WP_010928353.1	GMC family oxidoreductase	-
FYA54_RS10635	2229140..2230495	+	1356	WP_003809657.1	cytochrome c	-
FYA54_RS10640	2230507..2231247	-	741	WP_003809659.1	carbonic anhydrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6750.76 Da
• Isoelectric Point: 11.4018

>T137333 WP_010928352.1 NZ_CP043161:c2226250-2226068 [Bordetella parapertussis]
MNSTDLIQQPKADGWYRVHTVGSHHQYKHPTKPGKVTVPHPRKGLPTATQRSILKQAGLR

Nucleotide

• Length: 183 bp

>T137333 NZ_CP056697:c2246286-2246110 [Escherichia marmotae]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTCAG
GTTTCACGGGAGGCGCAGTGTCATGCCGCGTCACCCCAGCGAAGAGATTAAAGAACCATTGCGTAAAGCAATTCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 14270.92 Da
• Isoelectric Point: 4.3014

>AT137333 WP_010928351.1 NZ_CP043161:c2226045-2225656 [Bordetella parapertussis]
MLYPIHVSKDEGSAYGAAFPDFPGCFAAADELQDLPRAAQEAVEAHFYGETERIPAPSAPEAWANDEDYQGGYWMMVDID
LSKVNTKAVRLNISLPENLVHRIDEEAKARRLSRSAFLAMAAEHEMADA

Nucleotide

• Length: 390 bp

>AT137333 NZ_CP043161:c2226045-2225656 [Bordetella parapertussis]
ATGCTCTACCCGATCCATGTTTCCAAAGACGAAGGCAGCGCCTACGGGGCCGCCTTCCCTGATTTTCCCGGCTGCTTTGC
AGCCGCCGATGAACTCCAGGACCTCCCCCGCGCGGCGCAGGAAGCCGTTGAGGCGCACTTCTACGGAGAGACCGAGCGTA
TCCCCGCCCCGTCCGCCCCTGAAGCGTGGGCCAACGATGAGGACTATCAAGGCGGCTATTGGATGATGGTCGATATCGAC
CTGTCGAAGGTCAACACGAAGGCCGTGCGGCTCAACATCAGCCTGCCGGAAAACCTGGTTCACCGTATCGACGAGGAAGC
CAAGGCACGACGCCTTTCGCGCTCAGCGTTTCTGGCCATGGCTGCGGAGCACGAAATGGCCGACGCCTAG

Structures

Toxin

• AlphaFold DB: K0M8J0

Antitoxin

• AlphaFold DB: K0MFV7