Detailed information of TA system TA137332

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpA-brnA/BrnT_toxin-BrnA
• Location: 2091480..2092011
• Replicon: chromosome
• Accession: NZ_CP043161
• Organism: Bordetella parapertussis strain H105

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: K0MH61
• Locus tag: FYA54_RS09985
• Protein ID: WP_003812626.1
• Coordinates: 2091745..2092011 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: K0MF02
• Locus tag: FYA54_RS09980
• Protein ID: WP_003816743.1
• Coordinates: 2091480..2091758 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYA54_RS09950	2086910..2088004	+	1095	WP_003812637.1	TRAP transporter substrate-binding protein	-
FYA54_RS09955	2088216..2088845	+	630	WP_010928293.1	TRAP transporter small permease subunit	-
FYA54_RS09960	2088848..2090515	+	1668	WP_010928294.1	TRAP transporter large permease subunit	-
FYA54_RS09965	2090530..2091186	+	657	WP_010928295.1	phosphoribosylanthranilate isomerase	-
FYA54_RS09980	2091480..2091758	-	279	WP_003816743.1	BrnA antitoxin family protein	Antitoxin
FYA54_RS09985	2091745..2092011	-	267	WP_003812626.1	BrnT family toxin	Toxin
FYA54_RS09990	2092242..2093783	-	1542	WP_010928296.1	M81 family metallopeptidase	-
FYA54_RS09995	2093845..2094723	-	879	WP_041937387.1	tripartite tricarboxylate transporter substrate binding protein	-
FYA54_RS10000	2095120..2095752	+	633	WP_003812619.1	PAS domain-containing protein	-
FYA54_RS10005	2095863..2096573	+	711	WP_003812617.1	aquaporin Z	-
FYA54_RS10010	2096612..2096884	-	273	WP_003812615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-81)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (12-86)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10037.47 Da
• Isoelectric Point: 7.9923

>T137332 WP_003812626.1 NZ_CP043161:c2092011-2091745 [Bordetella parapertussis]
MDITYDPAKNDKNIADRGLSFELVCGFEWASALVVEDTRQVYAETRYQALGKIDGRLHMVVFTVRGESLRIISLRKANAR
EVARYEKA

Nucleotide

• Length: 267 bp

>T137332 NZ_CP043161:c2092011-2091745 [Bordetella parapertussis]
ATGGATATCACCTACGACCCCGCCAAGAACGACAAGAACATTGCCGATCGCGGCCTGTCGTTCGAGTTGGTGTGTGGCTT
CGAGTGGGCCAGCGCGCTGGTGGTTGAGGATACCCGCCAGGTCTACGCCGAAACGCGCTATCAGGCGCTGGGCAAAATCG
ATGGCCGGCTCCATATGGTGGTATTCACGGTGCGCGGCGAGTCGCTGCGCATCATCAGCCTGCGTAAGGCAAATGCTCGT
GAGGTAGCTCGTTATGAAAAAGCCTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10412.89 Da
• Isoelectric Point: 10.5548

>AT137332 WP_003816743.1 NZ_CP043161:c2091758-2091480 [Bordetella parapertussis]
MKKPDPEKIDRDNPEWTDAEFRRAKPAAEVLPESVHAMLGIRRRGPQKTPTKQVVTIRLSPDVVEAFKASGTGWQTRVDA
ALRDWLKTHQPG

Nucleotide

• Length: 279 bp

>AT137332 NZ_CP043161:c2091758-2091480 [Bordetella parapertussis]
ATGAAAAAGCCTGACCCCGAAAAGATTGACCGCGACAACCCCGAATGGACGGACGCGGAATTTCGGCGGGCCAAGCCGGC
CGCCGAAGTACTGCCCGAGTCGGTGCACGCGATGCTCGGCATTCGTCGCCGTGGGCCTCAAAAGACACCCACCAAACAGG
TCGTCACCATCCGGCTATCGCCTGACGTGGTAGAAGCCTTCAAGGCCTCCGGCACCGGTTGGCAGACTCGCGTGGATGCA
GCCCTGCGGGATTGGCTGAAGACGCACCAGCCTGGCTAG

Structures

Toxin

• AlphaFold DB: K0MH61

Antitoxin

• AlphaFold DB: K0MF02