Detailed information of TA system TA137331

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1504844..1505505
• Replicon: chromosome
• Accession: NZ_CP043161
• Organism: Bordetella parapertussis strain H105

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q7WAH5
• Locus tag: FYA54_RS07145
• Protein ID: WP_003812073.1
• Coordinates: 1504844..1505269 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FYA54_RS07150
• Protein ID: WP_003812071.1
• Coordinates: 1505266..1505505 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYA54_RS07125	1500658..1501635	+	978	WP_003812083.1	tripartite tricarboxylate transporter substrate binding protein	-
FYA54_RS07130	1501656..1502168	-	513	WP_010928017.1	hypothetical protein	-
FYA54_RS07135	1502667..1504172	+	1506	WP_010928018.1	tripartite tricarboxylate transporter permease	-
FYA54_RS07140	1504270..1504734	-	465	WP_003812075.1	MarR family transcriptional regulator	-
FYA54_RS07145	1504844..1505269	-	426	WP_003812073.1	PIN domain-containing protein	Toxin
FYA54_RS07150	1505266..1505505	-	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
FYA54_RS07155	1505579..1506421	-	843	WP_010928019.1	AraC family transcriptional regulator	-
FYA54_RS07160	1506559..1507104	+	546	WP_010928020.1	peroxidase-related enzyme	-
FYA54_RS07165	1507163..1507675	+	513	WP_003812062.1	redoxin domain-containing protein	-
FYA54_RS07170	1507756..1507989	+	234	WP_033447224.1	DUF2945 domain-containing protein	-
FYA54_RS07175	1507986..1508546	+	561	WP_010928021.1	DUF488 domain-containing protein	-
FYA54_RS07180	1508624..1509670	+	1047	WP_010928022.1	Dyp-type peroxidase	-
FYA54_RS07185	1509667..1510470	+	804	WP_003812055.1	bacteriocin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14811.22 Da
• Isoelectric Point: 6.3704

>T137331 WP_003812073.1 NZ_CP043161:c1505269-1504844 [Bordetella parapertussis]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRVLPLFMGHVLPFDT
AAADAYAAVMMRAAAAGHALCAIDGCIAAIATAHGLAIATRHPARFEAAGLAAVDPWHAAA

Nucleotide

• Length: 426 bp

>T137331 NZ_CP056697:2169725-2171047 [Escherichia marmotae]
ATGCCAAAACTTGTCACGTGGATGAACAACCAGCGGGTAGGCGAGTTGACGAAGCTGACCAACGGTGCCCATACCTTTAA
GTATGCGCCGGAGTGGTTGACCAACCGTTATGCCAGGCCATTGTCGCTTTCGCTGCCATTGCAAAGGGGGAATATCACCT
CTGATGCTGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGCGACCGCATCGTTAAACGTTATCAT
GCTAAATCCAGGCAACCGTTTGATTTATTGTCAGAAATAGGGCGAGATAGCGTTGGCGCCGTGACGTTATTACCAGAAGA
CGAAACCGTGACGCGCCCAATAATGGTATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGGGAGGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACTGCGCTG
CTCAGAATGGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCATATTATTAAATTGCCGATTGGTGAAAT
CAGACAGCCCAATGCGACGCTCGATCTCAGTCAGAGTGTTGATAATGAGTATTACTGTCTGCTGCTGGCAAAAGAATTCG
GGTTGAATGTTCCCGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGCTTTGACAGGCGCTGG
AATACTGAACGAACGGTTTTACTTCGCTTGCCGCAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCTGACGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTTCGCGATCGTTATG
ATTTTATGAAATTCCAGGTATTCCAGTGGTTGATTGGCTCGACAGACGGCCATGCGAAAAATTTCTCAGTGTTTATCCAG
GCCGGTGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTATTGGGTGGCGCGGGAATACATAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAGAAAAACGGAAATCGATAAAATATATCCGCGACATT
TTTTGGCGACAGCAAAGGCACTGAAATTTCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCC
GCAGCATTGGATAACGTGAAGGCTTCATTACCGGCAGATTTTCCGGAGAACGTGTTGACGGCAATTGAAACCAATGTGTT
GAGGTTGCACGGTCGGTTAAGCCGAGAATATGGAATTAAGTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT137331 WP_003812071.1 NZ_CP043161:c1505505-1505266 [Bordetella parapertussis]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT137331 NZ_CP056697:2169459-2169725 [Escherichia marmotae]
ATGATGAGCTTTCCGATGATCTATAGCCCAACGCAATTAGCAAATGCAATGAAACTTGTTCGTCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATCGGCATAAAACAGGCGACTATTTCCAATTTCGAAAATAACCCTGACAACACCACAC
TAACGACATTTTTTAAGATATTACAGTCACTTAATCTCTCGATGACGCTATGCGACACGAAAAATGACTCGCCAGAATCA
ACCGATCAGCAAGATCTGGAGTGGTAA

Structures

Toxin

• AlphaFold DB: Q7WAH5