Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2441866..2442460 Replicon chromosome
Accession NZ_CP043159
Organism Bordetella parapertussis strain H242

Toxin (Protein)


Gene name hicA Uniprot ID K0M8J0
Locus tag FYA56_RS11505 Protein ID WP_010928352.1
Coordinates 2441866..2442048 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID K0MFV7
Locus tag FYA56_RS11510 Protein ID WP_010928351.1
Coordinates 2442071..2442460 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA56_RS11485 2436869..2437609 + 741 WP_003809659.1 carbonic anhydrase -
FYA56_RS11490 2437621..2438976 - 1356 WP_003809657.1 cytochrome c -
FYA56_RS11495 2438987..2440756 - 1770 WP_010928353.1 GMC family oxidoreductase -
FYA56_RS11500 2440760..2441458 - 699 WP_003809653.1 gluconate 2-dehydrogenase subunit 3 family protein -
FYA56_RS11505 2441866..2442048 + 183 WP_010928352.1 type II toxin-antitoxin system HicA family toxin Toxin
FYA56_RS11510 2442071..2442460 + 390 WP_010928351.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FYA56_RS11520 2442726..2443502 - 777 WP_033448479.1 phosphate ABC transporter ATP-binding protein PstB -
FYA56_RS11525 2443547..2444404 - 858 WP_003809638.1 phosphate ABC transporter permease PstA -
FYA56_RS11530 2444426..2445442 - 1017 WP_010928350.1 phosphate ABC transporter permease subunit PstC -
FYA56_RS11535 2445577..2446617 - 1041 WP_003809635.1 phosphate ABC transporter substrate-binding protein PstS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-122)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6750.76 Da        Isoelectric Point: 11.4018

>T137327 WP_010928352.1 NZ_CP043159:2441866-2442048 [Bordetella parapertussis]
MNSTDLIQQPKADGWYRVHTVGSHHQYKHPTKPGKVTVPHPRKGLPTATQRSILKQAGLR

Download         Length: 183 bp

>T137327 NZ_CP056697:c519098-518757 [Escherichia marmotae]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGAATTATAATCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTTGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACTCCCCGCCACCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTCGCCTGA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 14270.92 Da        Isoelectric Point: 4.3014

>AT137327 WP_010928351.1 NZ_CP043159:2442071-2442460 [Bordetella parapertussis]
MLYPIHVSKDEGSAYGAAFPDFPGCFAAADELQDLPRAAQEAVEAHFYGETERIPAPSAPEAWANDEDYQGGYWMMVDID
LSKVNTKAVRLNISLPENLVHRIDEEAKARRLSRSAFLAMAAEHEMADA

Download         Length: 390 bp

>AT137327 NZ_CP056697:519093-519169 [Escherichia marmotae]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K0M8J0

Antitoxin

Source ID Structure
AlphaFold DB K0MFV7

References