Detailed information of TA system TA137321

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1504850..1505511
• Replicon: chromosome
• Accession: NZ_CP043155
• Organism: Bordetella parapertussis strain H314

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q7WAH5
• Locus tag: FYA60_RS07140
• Protein ID: WP_003812073.1
• Coordinates: 1504850..1505275 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FYA60_RS07145
• Protein ID: WP_003812071.1
• Coordinates: 1505272..1505511 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYA60_RS07120	1500664..1501641	+	978	WP_003812083.1	tripartite tricarboxylate transporter substrate binding protein	-
FYA60_RS07125	1501662..1502174	-	513	WP_010928017.1	hypothetical protein	-
FYA60_RS07130	1502673..1504178	+	1506	WP_010928018.1	tripartite tricarboxylate transporter permease	-
FYA60_RS07135	1504276..1504740	-	465	WP_003812075.1	MarR family transcriptional regulator	-
FYA60_RS07140	1504850..1505275	-	426	WP_003812073.1	PIN domain-containing protein	Toxin
FYA60_RS07145	1505272..1505511	-	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
FYA60_RS07150	1505585..1506427	-	843	WP_010928019.1	AraC family transcriptional regulator	-
FYA60_RS07155	1506565..1507110	+	546	WP_010928020.1	peroxidase-related enzyme	-
FYA60_RS07160	1507169..1507681	+	513	WP_003812062.1	redoxin domain-containing protein	-
FYA60_RS07165	1507762..1507995	+	234	WP_033447224.1	DUF2945 domain-containing protein	-
FYA60_RS07170	1507992..1508552	+	561	WP_010928021.1	DUF488 domain-containing protein	-
FYA60_RS07175	1508630..1509676	+	1047	WP_010928022.1	Dyp-type peroxidase	-
FYA60_RS07180	1509673..1510476	+	804	WP_003812055.1	bacteriocin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14811.22 Da
• Isoelectric Point: 6.3704

>T137321 WP_003812073.1 NZ_CP043155:c1505275-1504850 [Bordetella parapertussis]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRVLPLFMGHVLPFDT
AAADAYAAVMMRAAAAGHALCAIDGCIAAIATAHGLAIATRHPARFEAAGLAAVDPWHAAA

Nucleotide

• Length: 426 bp

>T137321 NZ_CP043155:c1505275-1504850 [Bordetella parapertussis]
ATGATCCTGCTCGACACCGACGTGCTGCTCGAGCCGCTGCGGCCGGCCCCCGACCCGGCCGTCGCGGCATGGCTGGATGC
CCAGCACGTCGAAACCCTGTACCTGGCCGCGCCCGGCGCGGCCGAAATCCAGCTCGGGCTGGCCCGCCTGCCGCGCGGCA
AGCGGGCCGAGGCCTTGCGCCACGAATTCGAGCGGCGCGTCCTGCCGCTGTTCATGGGCCATGTCCTGCCCTTCGACACG
GCCGCGGCCGATGCCTACGCCGCCGTCATGATGCGGGCCGCGGCGGCGGGCCATGCGCTGTGCGCAATCGATGGTTGCAT
CGCCGCCATCGCCACCGCGCACGGCCTGGCCATCGCCACGCGCCATCCGGCCAGGTTCGAGGCGGCCGGGCTCGCCGCCG
TCGATCCCTGGCACGCCGCCGCTTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT137321 WP_003812071.1 NZ_CP043155:c1505511-1505272 [Bordetella parapertussis]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT137321 NZ_CP056691:c3977995-3977729 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCCGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: Q7WAH5