Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3381677..3382313 Replicon chromosome
Accession NZ_CP043145
Organism Bordetella parapertussis strain H554

Toxin (Protein)


Gene name hicA Uniprot ID Q7W5Z1
Locus tag FYA70_RS15970 Protein ID WP_010928914.1
Coordinates 3381677..3381859 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q7W5Z0
Locus tag FYA70_RS15975 Protein ID WP_010928915.1
Coordinates 3381921..3382313 (+) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA70_RS15945 3377251..3377928 + 678 WP_010928910.1 HAD-IA family hydrolase -
FYA70_RS15950 3378146..3379333 + 1188 WP_135286160.1 MFS transporter -
FYA70_RS15960 3379908..3381128 + 1221 WP_010928912.1 ISL3-like element IS1001 family transposase -
FYA70_RS15970 3381677..3381859 + 183 WP_010928914.1 type II toxin-antitoxin system HicA family toxin Toxin
FYA70_RS15975 3381921..3382313 + 393 WP_010928915.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FYA70_RS15980 3382586..3383495 - 910 Protein_3137 LysR family transcriptional regulator -
FYA70_RS15985 3383620..3384594 + 975 WP_010928916.1 tripartite tricarboxylate transporter substrate binding protein -
FYA70_RS15990 3384629..3384988 + 360 WP_010928917.1 hypothetical protein -
FYA70_RS15995 3385055..3386227 + 1173 WP_010928918.1 thiolase domain-containing protein -
FYA70_RS16000 3386231..3386657 + 427 Protein_3141 OB-fold domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3379908..3381128 1220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6572.69 Da        Isoelectric Point: 10.9062

>T137320 WP_010928914.1 NZ_CP043145:3381677-3381859 [Bordetella parapertussis]
MDGKELIKQLERSGWTLRSVKGSHHVFAHPDRPGHISVPHPKKDLGIGLLNSILKAAGLK

Download         Length: 183 bp

>T137320 NZ_CP056691:c2842822-2842719 [Enterobacter hormaechei]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 14058.82 Da        Isoelectric Point: 4.2876

>AT137320 WP_010928915.1 NZ_CP043145:3381921-3382313 [Bordetella parapertussis]
VKYPIAIEPGSDTRAWGVVVPDLPGCFSAADEGIDQAIENAKEAIELWIETAIDSGAPIPAATNIANHQANPEFANWIWA
IADVDPAVLDETVERVNITIPRRILKRLDDRARAAGESRSSYIAHLAMTA

Download         Length: 393 bp

>AT137320 NZ_CP056691:2842714-2842915 [Enterobacter hormaechei]
CAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTCAATCGCCTTGCCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGTAAAAGTGGT
CTGAAAAAAAGCGTCAGAACATCACTAAATGTGAAAAACCGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q7W5Z1

Antitoxin

Source ID Structure
AlphaFold DB Q7W5Z0

References