Detailed information of TA system TA137291

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1504812..1505473
• Replicon: chromosome
• Accession: NZ_CP043120
• Organism: Bordetella parapertussis strain I139

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q7WAH5
• Locus tag: FYA96_RS07145
• Protein ID: WP_003812073.1
• Coordinates: 1504812..1505237 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FYA96_RS07150
• Protein ID: WP_003812071.1
• Coordinates: 1505234..1505473 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYA96_RS07125	1500626..1501603	+	978	WP_003812083.1	tripartite tricarboxylate transporter substrate binding protein	-
FYA96_RS07130	1501624..1502136	-	513	WP_010928017.1	hypothetical protein	-
FYA96_RS07135	1502635..1504140	+	1506	WP_010928018.1	tripartite tricarboxylate transporter permease	-
FYA96_RS07140	1504238..1504702	-	465	WP_003812075.1	MarR family transcriptional regulator	-
FYA96_RS07145	1504812..1505237	-	426	WP_003812073.1	PIN domain-containing protein	Toxin
FYA96_RS07150	1505234..1505473	-	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
FYA96_RS07155	1505547..1506389	-	843	WP_010928019.1	AraC family transcriptional regulator	-
FYA96_RS07160	1506527..1507072	+	546	WP_010928020.1	peroxidase-related enzyme	-
FYA96_RS07165	1507131..1507643	+	513	WP_003812062.1	redoxin domain-containing protein	-
FYA96_RS07170	1507724..1507957	+	234	WP_033447224.1	DUF2945 domain-containing protein	-
FYA96_RS07175	1507954..1508514	+	561	WP_010928021.1	DUF488 domain-containing protein	-
FYA96_RS07180	1508592..1509638	+	1047	WP_010928022.1	Dyp-type peroxidase	-
FYA96_RS07185	1509635..1510438	+	804	WP_003812055.1	bacteriocin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14811.22 Da
• Isoelectric Point: 6.3704

>T137291 WP_003812073.1 NZ_CP043120:c1505237-1504812 [Bordetella parapertussis]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRVLPLFMGHVLPFDT
AAADAYAAVMMRAAAAGHALCAIDGCIAAIATAHGLAIATRHPARFEAAGLAAVDPWHAAA

Nucleotide

• Length: 426 bp

>T137291 NZ_CP056665:c82377-81892 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAACCATTATCCAGCTCCCATCAACTAGCAGAGTTCGTCAGTGGTGAGGCAGTACTTGA
TGACTGGCTTAAACAGAGGGGATTAAAAAACCAAGCTCTTGGTGCAGCACGAACGTTCGTCGTTTGTAAAAGAGACACTA
AACAGGTTGTCGGTTTTTACTCTCTGGCCACCGGCAGCGTTAACCACGTGGAAGCAATGGGAAGCCTCAGGCGCAATATG
CCAGATCCAATTCCCGTAATCATACTTGCTCGCCTGGCAGTTGATGTTTCATACCGTGGCCAAGGGCTCGGGGCCGATTT
ACTGCATGATGCAGTTCTGCGCTGTTACCGTGTAGCTGAGAATATTGGAGTCCGTGCGATTATGGTTCATGCACTGACTG
AAGAAGCCAAAAACTTTTATCTTCACCATGGCTTTAAGGCATCACAAACTCAGGAACGGACATTGTTTTTAAAGTTACCA
CAGTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT137291 WP_003812071.1 NZ_CP043120:c1505473-1505234 [Bordetella parapertussis]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT137291 NZ_CP056665:c82631-82365 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAGCTCAACCTTAGAGCTAAAGAATCTCAAAGAGCACTTATTGATGCTGCAGCAGAGATTCTCCA
TAAATCACGCACGGACTTCATCCTGGAAATGGCATGTCAGGCTGCGGAGAATGTGATCCTCGATCGTCGCGTATTTAATT
TTAACGATGAGCAGTATGCAGAGTTTATCGATATGCTCGATGCACCGGTTTCGGATGAGGCGGCTATTGATAAACTTCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Toxin

• AlphaFold DB: Q7WAH5