Detailed information of TA system TA137285

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2959364..2960025
• Replicon: chromosome
• Accession: NZ_CP043117
• Organism: Bordetella parapertussis strain I267

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q7WAH5
• Locus tag: FYA99_RS13935
• Protein ID: WP_003812073.1
• Coordinates: 2959600..2960025 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FYA99_RS13930
• Protein ID: WP_003812071.1
• Coordinates: 2959364..2959603 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYA99_RS13895	2954399..2955202	-	804	WP_003812055.1	bacteriocin family protein	-
FYA99_RS13900	2955199..2956245	-	1047	WP_010928022.1	Dyp-type peroxidase	-
FYA99_RS13905	2956323..2956883	-	561	WP_010928021.1	DUF488 domain-containing protein	-
FYA99_RS13910	2956880..2957113	-	234	WP_033447224.1	DUF2945 domain-containing protein	-
FYA99_RS13915	2957194..2957706	-	513	WP_003812062.1	redoxin domain-containing protein	-
FYA99_RS13920	2957765..2958310	-	546	WP_010928020.1	peroxidase-related enzyme	-
FYA99_RS13925	2958448..2959290	+	843	WP_010928019.1	AraC family transcriptional regulator	-
FYA99_RS13930	2959364..2959603	+	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
FYA99_RS13935	2959600..2960025	+	426	WP_003812073.1	PIN domain-containing protein	Toxin
FYA99_RS13940	2960135..2960599	+	465	WP_003812075.1	MarR family transcriptional regulator	-
FYA99_RS13945	2960697..2962202	-	1506	WP_010928018.1	tripartite tricarboxylate transporter permease	-
FYA99_RS13950	2962701..2963213	+	513	WP_010928017.1	hypothetical protein	-
FYA99_RS13955	2963234..2964211	-	978	WP_003812083.1	tripartite tricarboxylate transporter substrate binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14811.22 Da
• Isoelectric Point: 6.3704

>T137285 WP_003812073.1 NZ_CP043117:2959600-2960025 [Bordetella parapertussis]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRVLPLFMGHVLPFDT
AAADAYAAVMMRAAAAGHALCAIDGCIAAIATAHGLAIATRHPARFEAAGLAAVDPWHAAA

Nucleotide

• Length: 426 bp

>T137285 NZ_CP043117:2959600-2960025 [Bordetella parapertussis]
ATGATCCTGCTCGACACCGACGTGCTGCTCGAGCCGCTGCGGCCGGCCCCCGACCCGGCCGTCGCGGCATGGCTGGATGC
CCAGCACGTCGAAACCCTGTACCTGGCCGCGCCCGGCGCGGCCGAAATCCAGCTCGGGCTGGCCCGCCTGCCGCGCGGCA
AGCGGGCCGAGGCCTTGCGCCACGAATTCGAGCGGCGCGTCCTGCCGCTGTTCATGGGCCATGTCCTGCCCTTCGACACG
GCCGCGGCCGATGCCTACGCCGCCGTCATGATGCGGGCCGCGGCGGCGGGCCATGCGCTGTGCGCAATCGATGGTTGCAT
CGCCGCCATCGCCACCGCGCACGGCCTGGCCATCGCCACGCGCCATCCGGCCAGGTTCGAGGCGGCCGGGCTCGCCGCCG
TCGATCCCTGGCACGCCGCCGCTTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT137285 WP_003812071.1 NZ_CP043117:2959364-2959603 [Bordetella parapertussis]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT137285 NZ_CP056663:c1191909-1191490 [Enterobacter hormaechei]
ATGAACTTTTCAGCAGCCATCAAAGCGGCAAACGATCTAACAAGGGAGCTCCCTTTCCTGGGCTCAAGCCCGTCGCGACA
AGATTATGAGGATGCTATGGGGTTGGTGGAGTATCTAATTGAGCATGACCCCGATAGTCCGCTGGTAGAGATGCTCACCG
CTAAAATCGATAAATACGAAAACGAGTCTCCGGAGTTTGCAGAATTTAACGCGCGTGTTGCCAGCATTCCGTCAGGCGTT
GCGTTATTGCGAACGCTGATGGATCAGTACCATCTCACTCAGAGCGATTTCGAAAACGAAATAGGTAAGAAGTCTCTGGT
GAGTCGGATCCTCAACGGACAGCGCACGTTAACGCTGGATCATATGCGCGCGCTGGCGAAGCGTTTTGGCGTGCAGGTAA
GTGCATTTGTGGGGAATTGA

Structures

Toxin

• AlphaFold DB: Q7WAH5