Detailed information of TA system TA137284

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpA-brnA/BrnT_toxin-BrnA
• Location: 2372842..2373373
• Replicon: chromosome
• Accession: NZ_CP043117
• Organism: Bordetella parapertussis strain I267

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: K0MH61
• Locus tag: FYA99_RS11100
• Protein ID: WP_003812626.1
• Coordinates: 2372842..2373108 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: K0MF02
• Locus tag: FYA99_RS11105
• Protein ID: WP_003816743.1
• Coordinates: 2373095..2373373 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYA99_RS11075	2367969..2368241	+	273	WP_003812615.1	hypothetical protein	-
FYA99_RS11080	2368280..2368990	-	711	WP_003812617.1	aquaporin Z	-
FYA99_RS11085	2369101..2369733	-	633	WP_003812619.1	PAS domain-containing protein	-
FYA99_RS11090	2370130..2371008	+	879	WP_041937387.1	tripartite tricarboxylate transporter substrate binding protein	-
FYA99_RS11095	2371070..2372611	+	1542	WP_153570231.1	M81 family metallopeptidase	-
FYA99_RS11100	2372842..2373108	+	267	WP_003812626.1	BrnT family toxin	Toxin
FYA99_RS11105	2373095..2373373	+	279	WP_003816743.1	BrnA antitoxin family protein	Antitoxin
FYA99_RS11115	2373670..2374326	-	657	WP_010928295.1	phosphoribosylanthranilate isomerase	-
FYA99_RS11120	2374341..2376007	-	1667	Protein_2183	TRAP transporter large permease subunit	-
FYA99_RS11125	2376010..2376639	-	630	WP_153570232.1	TRAP transporter small permease subunit	-
FYA99_RS11130	2376851..2377945	-	1095	WP_003812637.1	TRAP transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-81)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (12-86)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10037.47 Da
• Isoelectric Point: 7.9923

>T137284 WP_003812626.1 NZ_CP043117:2372842-2373108 [Bordetella parapertussis]
MDITYDPAKNDKNIADRGLSFELVCGFEWASALVVEDTRQVYAETRYQALGKIDGRLHMVVFTVRGESLRIISLRKANAR
EVARYEKA

Nucleotide

• Length: 267 bp

>T137284 NZ_CP043117:2372842-2373108 [Bordetella parapertussis]
ATGGATATCACCTACGACCCCGCCAAGAACGACAAGAACATTGCCGATCGCGGCCTGTCGTTCGAGTTGGTGTGTGGCTT
CGAGTGGGCCAGCGCGCTGGTGGTTGAGGATACCCGCCAGGTCTACGCCGAAACGCGCTATCAGGCGCTGGGCAAAATCG
ATGGCCGGCTCCATATGGTGGTATTCACGGTGCGCGGCGAGTCGCTGCGCATCATCAGCCTGCGTAAGGCAAATGCTCGT
GAGGTAGCTCGTTATGAAAAAGCCTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10412.89 Da
• Isoelectric Point: 10.5548

>AT137284 WP_003816743.1 NZ_CP043117:2373095-2373373 [Bordetella parapertussis]
MKKPDPEKIDRDNPEWTDAEFRRAKPAAEVLPESVHAMLGIRRRGPQKTPTKQVVTIRLSPDVVEAFKASGTGWQTRVDA
ALRDWLKTHQPG

Nucleotide

• Length: 279 bp

>AT137284 NZ_CP056663:c1086287-1085913 [Enterobacter hormaechei]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAATGAGCTGATCGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACGAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Structures

Toxin

• AlphaFold DB: K0MH61

Antitoxin

• AlphaFold DB: K0MF02