Detailed information of TA system TA137281

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1082512..1083148
• Replicon: chromosome
• Accession: NZ_CP043117
• Organism: Bordetella parapertussis strain I267

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q7W5Z1
• Locus tag: FYA99_RS05105
• Protein ID: WP_010928914.1
• Coordinates: 1082966..1083148 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q7W5Z0
• Locus tag: FYA99_RS05100
• Protein ID: WP_010928915.1
• Coordinates: 1082512..1082904 (-)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYA99_RS05075	1078168..1078594	-	427	Protein_995	OB-fold domain-containing protein	-
FYA99_RS05080	1078598..1079770	-	1173	WP_010928918.1	thiolase domain-containing protein	-
FYA99_RS05085	1079837..1080196	-	360	WP_010928917.1	hypothetical protein	-
FYA99_RS05090	1080231..1081205	-	975	WP_010928916.1	tripartite tricarboxylate transporter substrate binding protein	-
FYA99_RS05095	1081330..1082239	+	910	Protein_999	LysR family transcriptional regulator	-
FYA99_RS05100	1082512..1082904	-	393	WP_010928915.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FYA99_RS05105	1082966..1083148	-	183	WP_010928914.1	type II toxin-antitoxin system HicA family toxin	Toxin
FYA99_RS05115	1083697..1084917	-	1221	WP_010928912.1	ISL3-like element IS1001 family transposase	-
FYA99_RS05125	1085492..1086679	-	1188	WP_010928911.1	MFS transporter	-
FYA99_RS05130	1086897..1087574	-	678	WP_010928910.1	HAD-IA family hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1083697..1084917	1220

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6572.69 Da
• Isoelectric Point: 10.9062

>T137281 WP_010928914.1 NZ_CP043117:c1083148-1082966 [Bordetella parapertussis]
MDGKELIKQLERSGWTLRSVKGSHHVFAHPDRPGHISVPHPKKDLGIGLLNSILKAAGLK

Nucleotide

• Length: 183 bp

>T137281 NZ_CP056647:5042826-5043137 [Citrobacter sp. RHBSTW-00229]
ATGCATGTTATCAGCCGAAAACCTTTCAACGAGGCAATACTCCGTTTTCCAAACCACATGGCAGCACTCGTTGATTTGCT
GAATATTTTAGAGAAAAAAATGTTCCACACTCCTGAAGAGATGAAGCAGTACATACCTTCACTGGATAATTTTAAATACA
GAAATAAATGGTGGGTGATTAATGTTTCAGGTAACTGCTTGAGACTTATTGCCTATATTGATTTCAAACTGCAAAAGGTA
TTTGTGAAGCATATCGTTCACCATGCCGAGTATGACAGACTAACCACATACTATCGGGGTCACAAAGAATGA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 14058.82 Da
• Isoelectric Point: 4.2876

>AT137281 WP_010928915.1 NZ_CP043117:c1082904-1082512 [Bordetella parapertussis]
VKYPIAIEPGSDTRAWGVVVPDLPGCFSAADEGIDQAIENAKEAIELWIETAIDSGAPIPAATNIANHQANPEFANWIWA
IADVDPAVLDETVERVNITIPRRILKRLDDRARAAGESRSSYIAHLAMTA

Nucleotide

• Length: 393 bp

>AT137281 NZ_CP043117:c1082904-1082512 [Bordetella parapertussis]
GTGAAATATCCCATTGCCATTGAACCCGGCAGCGACACGCGCGCCTGGGGAGTCGTTGTTCCTGATCTGCCCGGCTGCTT
TTCCGCAGCGGACGAAGGGATTGATCAAGCAATCGAGAACGCCAAGGAAGCCATTGAGTTGTGGATTGAAACGGCCATCG
ACTCCGGCGCCCCCATTCCTGCGGCAACCAACATAGCCAATCATCAGGCCAATCCTGAGTTCGCCAACTGGATTTGGGCG
ATTGCTGATGTCGATCCTGCAGTCTTGGATGAAACTGTCGAGCGCGTGAACATCACAATCCCGCGCCGAATTCTCAAGCG
CCTGGATGATCGCGCCCGCGCCGCCGGCGAAAGCCGGAGCAGCTACATCGCACATCTCGCCATGACTGCCTGA

Structures

Toxin

• AlphaFold DB: Q7W5Z1

Antitoxin

• AlphaFold DB: Q7W5Z0