Detailed information of TA system TA137274

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 3162672..3163333
• Replicon: chromosome
• Accession: NZ_CP043115
• Organism: Bordetella parapertussis strain I301

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q7WAH5
• Locus tag: FYB02_RS14975
• Protein ID: WP_003812073.1
• Coordinates: 3162908..3163333 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FYB02_RS14970
• Protein ID: WP_003812071.1
• Coordinates: 3162672..3162911 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB02_RS14935	3157707..3158510	-	804	WP_003812055.1	bacteriocin family protein	-
FYB02_RS14940	3158507..3159553	-	1047	WP_010928022.1	Dyp-type peroxidase	-
FYB02_RS14945	3159631..3160191	-	561	WP_010928021.1	DUF488 domain-containing protein	-
FYB02_RS14950	3160188..3160421	-	234	WP_033447224.1	DUF2945 domain-containing protein	-
FYB02_RS14955	3160502..3161014	-	513	WP_003812062.1	redoxin domain-containing protein	-
FYB02_RS14960	3161073..3161618	-	546	WP_010928020.1	peroxidase-related enzyme	-
FYB02_RS14965	3161756..3162598	+	843	WP_010928019.1	AraC family transcriptional regulator	-
FYB02_RS14970	3162672..3162911	+	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
FYB02_RS14975	3162908..3163333	+	426	WP_003812073.1	PIN domain-containing protein	Toxin
FYB02_RS14980	3163443..3163907	+	465	WP_003812075.1	MarR family transcriptional regulator	-
FYB02_RS14985	3164005..3165510	-	1506	WP_010928018.1	tripartite tricarboxylate transporter permease	-
FYB02_RS14990	3166009..3166521	+	513	WP_010928017.1	hypothetical protein	-
FYB02_RS14995	3166542..3167519	-	978	WP_003812083.1	tripartite tricarboxylate transporter substrate binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14811.22 Da
• Isoelectric Point: 6.3704

>T137274 WP_003812073.1 NZ_CP043115:3162908-3163333 [Bordetella parapertussis]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRVLPLFMGHVLPFDT
AAADAYAAVMMRAAAAGHALCAIDGCIAAIATAHGLAIATRHPARFEAAGLAAVDPWHAAA

Nucleotide

• Length: 426 bp

>T137274 NZ_CP056647:c1345270-1345052 [Citrobacter sp. RHBSTW-00229]
ATGTCCGATAAACCATTAACTAAAACTGATTATTTGATGCGCCTGCGACGTTGTCAGACAATTGACACACTTGAGCGCGT
TATTGAAAAAAATAAATATGAATTGTCCGACAACGAACTGGCTGTATTTTACTCAGCAGCAGATCACCGCCTTGCTGAAT
TGACTATGAATAAGCTCTACGACAAGATTCCAACTTCTGTTTGGAAATTCATTCGCTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT137274 WP_003812071.1 NZ_CP043115:3162672-3162911 [Bordetella parapertussis]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT137274 NZ_CP043115:3162672-3162911 [Bordetella parapertussis]
GTGTCTTCGATTACGGTAAGAAATGTTCCCGAGGAAGTGCATCGCGCCTTGCGCGTACGCGCGGCCACGCATGGGCGCAG
CACCGAGGCCGAGATCCGCGCCATCCTGGAAAACGCCGTGCTGCCCGATGGCCGCGTCAAGCTGGGCACCCTGCTCAGCC
ACATCGGCCGCGGCGCGCGCGGCATGGACCTGACCATCGAGCGCAATCCGGCGCCCGCTCGCCCGGCCAGCTTCGAATGA

Structures

Toxin

• AlphaFold DB: Q7WAH5