Detailed information of TA system TA137273

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpA-brnA/BrnT_toxin-BrnA
• Location: 2576156..2576687
• Replicon: chromosome
• Accession: NZ_CP043115
• Organism: Bordetella parapertussis strain I301

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: K0MH61
• Locus tag: FYB02_RS12140
• Protein ID: WP_003812626.1
• Coordinates: 2576156..2576422 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: K0MF02
• Locus tag: FYB02_RS12145
• Protein ID: WP_003816743.1
• Coordinates: 2576409..2576687 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB02_RS12115	2571283..2571555	+	273	WP_003812615.1	hypothetical protein	-
FYB02_RS12120	2571594..2572304	-	711	WP_003812617.1	aquaporin Z	-
FYB02_RS12125	2572415..2573047	-	633	WP_003812619.1	PAS domain-containing protein	-
FYB02_RS12130	2573444..2574322	+	879	WP_041937387.1	tripartite tricarboxylate transporter substrate binding protein	-
FYB02_RS12135	2574384..2575925	+	1542	WP_010928296.1	M81 family metallopeptidase	-
FYB02_RS12140	2576156..2576422	+	267	WP_003812626.1	BrnT family toxin	Toxin
FYB02_RS12145	2576409..2576687	+	279	WP_003816743.1	BrnA antitoxin family protein	Antitoxin
FYB02_RS12155	2576982..2577638	-	657	WP_010928295.1	phosphoribosylanthranilate isomerase	-
FYB02_RS12160	2577653..2579319	-	1667	Protein_2389	TRAP transporter large permease subunit	-
FYB02_RS12165	2579322..2579951	-	630	WP_010928293.1	TRAP transporter small permease subunit	-
FYB02_RS12170	2580163..2581257	-	1095	WP_003812637.1	TRAP transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-81)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (12-86)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10037.47 Da
• Isoelectric Point: 7.9923

>T137273 WP_003812626.1 NZ_CP043115:2576156-2576422 [Bordetella parapertussis]
MDITYDPAKNDKNIADRGLSFELVCGFEWASALVVEDTRQVYAETRYQALGKIDGRLHMVVFTVRGESLRIISLRKANAR
EVARYEKA

Nucleotide

• Length: 267 bp

>T137273 NZ_CP056647:763668-764009 [Citrobacter sp. RHBSTW-00229]
ATGAACACCTCTCCTGCAACAAATCAGCGGGTAGCGAAGCCATGCCCGTCGCCTGTGGCCGTCTGGCAGATGTTACTTAC
CCGTCTACTTGCACAACACTATGGCCTGGCCCTGAGTGACACGCCATTCTGCGATGAAACAGTCATTCAGGAACATATCA
ACGCAGGCGTTACTCTTGCCGATGCCGTGAACTTTCTGGTGGAAAAATACGAACTCGTTCGTATCGATCGCAAAGGATTT
AGCTGGCAGGAACAATCGCCTTATCTGCGGGCTGTAGACATTTTGCGGGCGCGACAGGCAATGGGGTTATTACGACAAGG
CCATAATCTTTCGACACGCTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10412.89 Da
• Isoelectric Point: 10.5548

>AT137273 WP_003816743.1 NZ_CP043115:2576409-2576687 [Bordetella parapertussis]
MKKPDPEKIDRDNPEWTDAEFRRAKPAAEVLPESVHAMLGIRRRGPQKTPTKQVVTIRLSPDVVEAFKASGTGWQTRVDA
ALRDWLKTHQPG

Nucleotide

• Length: 279 bp

>AT137273 NZ_CP056647:763288-763632 [Citrobacter sp. RHBSTW-00229]
ATGAAAAAAGACACAGCCAATGAAGTAGTGGATACGCTGCGATGGGGACTGAAATGCGACATCACACCACATTTCGGGGC
CCGTCTGGTGCAGGAAGGCAACCGCCTGCATTACCTCGCCGATCGGGCCAGCATAATTGGTCAGTTCAGTAAAGCTGATT
TACGCCATCTCAACCAGGCTTTCCCCTTGTTGGTGAAGCAAATGGAACTCATGCTCACCAGCGGAGAACTTAATCCCCGG
CACCAGCACTGCGTCACGCTGTATGCGAAGAGATTAACCTGTGAAGCCGATACGCTCGGCTCCTGTGGCTACGTTTACAT
CACCATTTACCCCACTCAACGCTGA

Structures

Toxin

• AlphaFold DB: K0MH61

Antitoxin

• AlphaFold DB: K0MF02