Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA-HicB |
Location | 2441918..2442512 | Replicon | chromosome |
Accession | NZ_CP043115 | ||
Organism | Bordetella parapertussis strain I301 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | K0M8J0 |
Locus tag | FYB02_RS11505 | Protein ID | WP_010928352.1 |
Coordinates | 2441918..2442100 (+) | Length | 61 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | K0MFV7 |
Locus tag | FYB02_RS11510 | Protein ID | WP_010928351.1 |
Coordinates | 2442123..2442512 (+) | Length | 130 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FYB02_RS11485 | 2436921..2437661 | + | 741 | WP_003809659.1 | carbonic anhydrase | - |
FYB02_RS11490 | 2437673..2439028 | - | 1356 | WP_003809657.1 | cytochrome c | - |
FYB02_RS11495 | 2439039..2440808 | - | 1770 | WP_010928353.1 | GMC family oxidoreductase | - |
FYB02_RS11500 | 2440812..2441510 | - | 699 | WP_003809653.1 | gluconate 2-dehydrogenase subunit 3 family protein | - |
FYB02_RS11505 | 2441918..2442100 | + | 183 | WP_010928352.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
FYB02_RS11510 | 2442123..2442512 | + | 390 | WP_010928351.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
FYB02_RS11520 | 2442778..2443554 | - | 777 | WP_033448479.1 | phosphate ABC transporter ATP-binding protein PstB | - |
FYB02_RS11525 | 2443599..2444456 | - | 858 | WP_003809638.1 | phosphate ABC transporter permease PstA | - |
FYB02_RS11530 | 2444478..2445494 | - | 1017 | WP_010928350.1 | phosphate ABC transporter permease subunit PstC | - |
FYB02_RS11535 | 2445629..2446669 | - | 1041 | WP_003809635.1 | phosphate ABC transporter substrate-binding protein PstS | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6750.76 Da Isoelectric Point: 11.4018
>T137272 WP_010928352.1 NZ_CP043115:2441918-2442100 [Bordetella parapertussis]
MNSTDLIQQPKADGWYRVHTVGSHHQYKHPTKPGKVTVPHPRKGLPTATQRSILKQAGLR
MNSTDLIQQPKADGWYRVHTVGSHHQYKHPTKPGKVTVPHPRKGLPTATQRSILKQAGLR
Download Length: 183 bp
>T137272 NZ_CP043115:2441918-2442100 [Bordetella parapertussis]
ATGAACAGCACAGACCTGATCCAGCAACCGAAGGCCGACGGCTGGTATCGCGTGCATACCGTGGGTTCACACCACCAGTA
CAAGCACCCGACCAAGCCCGGCAAGGTCACCGTGCCGCATCCCAGGAAGGGCCTGCCGACAGCGACACAGCGCAGCATCC
TTAAGCAAGCCGGCCTGCGATAA
ATGAACAGCACAGACCTGATCCAGCAACCGAAGGCCGACGGCTGGTATCGCGTGCATACCGTGGGTTCACACCACCAGTA
CAAGCACCCGACCAAGCCCGGCAAGGTCACCGTGCCGCATCCCAGGAAGGGCCTGCCGACAGCGACACAGCGCAGCATCC
TTAAGCAAGCCGGCCTGCGATAA
Antitoxin
Download Length: 130 a.a. Molecular weight: 14270.92 Da Isoelectric Point: 4.3014
>AT137272 WP_010928351.1 NZ_CP043115:2442123-2442512 [Bordetella parapertussis]
MLYPIHVSKDEGSAYGAAFPDFPGCFAAADELQDLPRAAQEAVEAHFYGETERIPAPSAPEAWANDEDYQGGYWMMVDID
LSKVNTKAVRLNISLPENLVHRIDEEAKARRLSRSAFLAMAAEHEMADA
MLYPIHVSKDEGSAYGAAFPDFPGCFAAADELQDLPRAAQEAVEAHFYGETERIPAPSAPEAWANDEDYQGGYWMMVDID
LSKVNTKAVRLNISLPENLVHRIDEEAKARRLSRSAFLAMAAEHEMADA
Download Length: 390 bp
>AT137272 NZ_CP043115:2442123-2442512 [Bordetella parapertussis]
ATGCTCTACCCGATCCATGTTTCCAAAGACGAAGGCAGCGCCTACGGGGCCGCCTTCCCTGATTTTCCCGGCTGCTTTGC
AGCCGCCGATGAACTCCAGGACCTCCCCCGCGCGGCGCAGGAAGCCGTTGAGGCGCACTTCTACGGAGAGACCGAGCGTA
TCCCCGCCCCGTCCGCCCCTGAAGCGTGGGCCAACGATGAGGACTATCAAGGCGGCTATTGGATGATGGTCGATATCGAC
CTGTCGAAGGTCAACACGAAGGCCGTGCGGCTCAACATCAGCCTGCCGGAAAACCTGGTTCACCGTATCGACGAGGAAGC
CAAGGCACGACGCCTTTCGCGCTCAGCGTTTCTGGCCATGGCTGCGGAGCACGAAATGGCCGACGCCTAG
ATGCTCTACCCGATCCATGTTTCCAAAGACGAAGGCAGCGCCTACGGGGCCGCCTTCCCTGATTTTCCCGGCTGCTTTGC
AGCCGCCGATGAACTCCAGGACCTCCCCCGCGCGGCGCAGGAAGCCGTTGAGGCGCACTTCTACGGAGAGACCGAGCGTA
TCCCCGCCCCGTCCGCCCCTGAAGCGTGGGCCAACGATGAGGACTATCAAGGCGGCTATTGGATGATGGTCGATATCGAC
CTGTCGAAGGTCAACACGAAGGCCGTGCGGCTCAACATCAGCCTGCCGGAAAACCTGGTTCACCGTATCGACGAGGAAGC
CAAGGCACGACGCCTTTCGCGCTCAGCGTTTCTGGCCATGGCTGCGGAGCACGAAATGGCCGACGCCTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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