Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2441918..2442512 Replicon chromosome
Accession NZ_CP043115
Organism Bordetella parapertussis strain I301

Toxin (Protein)


Gene name hicA Uniprot ID K0M8J0
Locus tag FYB02_RS11505 Protein ID WP_010928352.1
Coordinates 2441918..2442100 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID K0MFV7
Locus tag FYB02_RS11510 Protein ID WP_010928351.1
Coordinates 2442123..2442512 (+) Length 130 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYB02_RS11485 2436921..2437661 + 741 WP_003809659.1 carbonic anhydrase -
FYB02_RS11490 2437673..2439028 - 1356 WP_003809657.1 cytochrome c -
FYB02_RS11495 2439039..2440808 - 1770 WP_010928353.1 GMC family oxidoreductase -
FYB02_RS11500 2440812..2441510 - 699 WP_003809653.1 gluconate 2-dehydrogenase subunit 3 family protein -
FYB02_RS11505 2441918..2442100 + 183 WP_010928352.1 type II toxin-antitoxin system HicA family toxin Toxin
FYB02_RS11510 2442123..2442512 + 390 WP_010928351.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FYB02_RS11520 2442778..2443554 - 777 WP_033448479.1 phosphate ABC transporter ATP-binding protein PstB -
FYB02_RS11525 2443599..2444456 - 858 WP_003809638.1 phosphate ABC transporter permease PstA -
FYB02_RS11530 2444478..2445494 - 1017 WP_010928350.1 phosphate ABC transporter permease subunit PstC -
FYB02_RS11535 2445629..2446669 - 1041 WP_003809635.1 phosphate ABC transporter substrate-binding protein PstS -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 61 a.a.        Molecular weight: 6750.76 Da        Isoelectric Point: 11.4018

>T137272 WP_010928352.1 NZ_CP043115:2441918-2442100 [Bordetella parapertussis]
MNSTDLIQQPKADGWYRVHTVGSHHQYKHPTKPGKVTVPHPRKGLPTATQRSILKQAGLR

Download         Length: 183 bp

>T137272 NZ_CP043115:2441918-2442100 [Bordetella parapertussis]
ATGAACAGCACAGACCTGATCCAGCAACCGAAGGCCGACGGCTGGTATCGCGTGCATACCGTGGGTTCACACCACCAGTA
CAAGCACCCGACCAAGCCCGGCAAGGTCACCGTGCCGCATCCCAGGAAGGGCCTGCCGACAGCGACACAGCGCAGCATCC
TTAAGCAAGCCGGCCTGCGATAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 14270.92 Da        Isoelectric Point: 4.3014

>AT137272 WP_010928351.1 NZ_CP043115:2442123-2442512 [Bordetella parapertussis]
MLYPIHVSKDEGSAYGAAFPDFPGCFAAADELQDLPRAAQEAVEAHFYGETERIPAPSAPEAWANDEDYQGGYWMMVDID
LSKVNTKAVRLNISLPENLVHRIDEEAKARRLSRSAFLAMAAEHEMADA

Download         Length: 390 bp

>AT137272 NZ_CP043115:2442123-2442512 [Bordetella parapertussis]
ATGCTCTACCCGATCCATGTTTCCAAAGACGAAGGCAGCGCCTACGGGGCCGCCTTCCCTGATTTTCCCGGCTGCTTTGC
AGCCGCCGATGAACTCCAGGACCTCCCCCGCGCGGCGCAGGAAGCCGTTGAGGCGCACTTCTACGGAGAGACCGAGCGTA
TCCCCGCCCCGTCCGCCCCTGAAGCGTGGGCCAACGATGAGGACTATCAAGGCGGCTATTGGATGATGGTCGATATCGAC
CTGTCGAAGGTCAACACGAAGGCCGTGCGGCTCAACATCAGCCTGCCGGAAAACCTGGTTCACCGTATCGACGAGGAAGC
CAAGGCACGACGCCTTTCGCGCTCAGCGTTTCTGGCCATGGCTGCGGAGCACGAAATGGCCGACGCCTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB K0M8J0


Antitoxin

Source ID Structure
AlphaFold DB K0MFV7

References