Detailed information of TA system TA137266

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1504916..1505577
• Replicon: chromosome
• Accession: NZ_CP043114
• Organism: Bordetella parapertussis strain I308

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q7WAH5
• Locus tag: FYB03_RS07145
• Protein ID: WP_003812073.1
• Coordinates: 1504916..1505341 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FYB03_RS07150
• Protein ID: WP_003812071.1
• Coordinates: 1505338..1505577 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB03_RS07125	1500730..1501707	+	978	WP_003812083.1	tripartite tricarboxylate transporter substrate binding protein	-
FYB03_RS07130	1501728..1502240	-	513	WP_010928017.1	hypothetical protein	-
FYB03_RS07135	1502739..1504244	+	1506	WP_010928018.1	tripartite tricarboxylate transporter permease	-
FYB03_RS07140	1504342..1504806	-	465	WP_003812075.1	MarR family transcriptional regulator	-
FYB03_RS07145	1504916..1505341	-	426	WP_003812073.1	PIN domain-containing protein	Toxin
FYB03_RS07150	1505338..1505577	-	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
FYB03_RS07155	1505651..1506493	-	843	WP_010928019.1	AraC family transcriptional regulator	-
FYB03_RS07160	1506631..1507176	+	546	WP_010928020.1	peroxidase-related enzyme	-
FYB03_RS07165	1507235..1507747	+	513	WP_003812062.1	redoxin domain-containing protein	-
FYB03_RS07170	1507828..1508061	+	234	WP_033447224.1	DUF2945 domain-containing protein	-
FYB03_RS07175	1508058..1508618	+	561	WP_010928021.1	DUF488 domain-containing protein	-
FYB03_RS07180	1508696..1509742	+	1047	WP_010928022.1	Dyp-type peroxidase	-
FYB03_RS07185	1509739..1510542	+	804	WP_003812055.1	bacteriocin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14811.22 Da
• Isoelectric Point: 6.3704

>T137266 WP_003812073.1 NZ_CP043114:c1505341-1504916 [Bordetella parapertussis]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRVLPLFMGHVLPFDT
AAADAYAAVMMRAAAAGHALCAIDGCIAAIATAHGLAIATRHPARFEAAGLAAVDPWHAAA

Nucleotide

• Length: 426 bp

>T137266 NZ_CP056644:4525024-4525311 [Citrobacter freundii]
ATGAGTTATACGGTAAAATTCAGGGAAGATGCGCTGAAAGAATGGCAAAAACTGGATAAAACCATTCAGCAGCAGCTTGC
CAAAGAACTCAAGAAATGCGGTGAAAATCCGCATGTCCCCTCCGCGAAGCTCAGGGGAATAAAAGATTGCTATAAAATCC
AACTACGCACTTCAAGGTTCCGTCTTGTTTATCAAGTTATTGACGACACCCTGGTCATTGCTGTCGTTGCCGTCGGTAAA
CGCGAGCGTAGTGAAGTTTATAATCTTGCCAGCGAAAGACTACGTTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT137266 WP_003812071.1 NZ_CP043114:c1505577-1505338 [Bordetella parapertussis]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT137266 NZ_CP043114:c1505577-1505338 [Bordetella parapertussis]
GTGTCTTCGATTACGGTAAGAAATGTTCCCGAGGAAGTGCATCGCGCCTTGCGCGTACGCGCGGCCACGCATGGGCGCAG
CACCGAGGCCGAGATCCGCGCCATCCTGGAAAACGCCGTGCTGCCCGATGGCCGCGTCAAGCTGGGCACCCTGCTCAGCC
ACATCGGCCGCGGCGCGCGCGGCATGGACCTGACCATCGAGCGCAATCCGGCGCCCGCTCGCCCGGCCAGCTTCGAATGA

Structures

Toxin

• AlphaFold DB: Q7WAH5