Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2225684..2226278 Replicon chromosome
Accession NZ_CP043111
Organism Bordetella parapertussis strain I457

Toxin (Protein)


Gene name hicA Uniprot ID K0M8J0
Locus tag FYB06_RS10620 Protein ID WP_010928352.1
Coordinates 2226096..2226278 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID K0MFV7
Locus tag FYB06_RS10615 Protein ID WP_010928351.1
Coordinates 2225684..2226073 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYB06_RS10590 2221527..2222567 + 1041 WP_003809635.1 phosphate ABC transporter substrate-binding protein PstS -
FYB06_RS10595 2222702..2223718 + 1017 WP_010928350.1 phosphate ABC transporter permease subunit PstC -
FYB06_RS10600 2223740..2224597 + 858 WP_003809638.1 phosphate ABC transporter permease PstA -
FYB06_RS10605 2224642..2225418 + 777 WP_033448479.1 phosphate ABC transporter ATP-binding protein PstB -
FYB06_RS10615 2225684..2226073 - 390 WP_010928351.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FYB06_RS10620 2226096..2226278 - 183 WP_010928352.1 type II toxin-antitoxin system HicA family toxin Toxin
FYB06_RS10625 2226686..2227384 + 699 WP_003809653.1 gluconate 2-dehydrogenase subunit 3 family protein -
FYB06_RS10630 2227388..2229157 + 1770 WP_010928353.1 GMC family oxidoreductase -
FYB06_RS10635 2229168..2230523 + 1356 WP_003809657.1 cytochrome c -
FYB06_RS10640 2230535..2231275 - 741 WP_003809659.1 carbonic anhydrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-122)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6750.76 Da        Isoelectric Point: 11.4018

>T137253 WP_010928352.1 NZ_CP043111:c2226278-2226096 [Bordetella parapertussis]
MNSTDLIQQPKADGWYRVHTVGSHHQYKHPTKPGKVTVPHPRKGLPTATQRSILKQAGLR

Download         Length: 183 bp

>T137253 NZ_CP043111:c2226278-2226096 [Bordetella parapertussis]
ATGAACAGCACAGACCTGATCCAGCAACCGAAGGCCGACGGCTGGTATCGCGTGCATACCGTGGGTTCACACCACCAGTA
CAAGCACCCGACCAAGCCCGGCAAGGTCACCGTGCCGCATCCCAGGAAGGGCCTGCCGACAGCGACACAGCGCAGCATCC
TTAAGCAAGCCGGCCTGCGATAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 14270.92 Da        Isoelectric Point: 4.3014

>AT137253 WP_010928351.1 NZ_CP043111:c2226073-2225684 [Bordetella parapertussis]
MLYPIHVSKDEGSAYGAAFPDFPGCFAAADELQDLPRAAQEAVEAHFYGETERIPAPSAPEAWANDEDYQGGYWMMVDID
LSKVNTKAVRLNISLPENLVHRIDEEAKARRLSRSAFLAMAAEHEMADA

Download         Length: 390 bp

>AT137253 NZ_CP056623:254193-254432 [Citrobacter freundii]
ATGCAGGCTACAGCTGCTCGCCAGAAAAAAACCGTCAGTGTCACCCTTGAGCCAATGCTCGTACAGCAGGCAAAAGACGC
TGGGATTAACTTGTCCGCCACGCTGGCAGAAGCGCTTCAGAGCAAACTGAAGGCCAGTGCAGCGGAAGAATGGAAACGAC
AGAATCGTGCTGGTATTCAGGAGTTGAACCGCATCACTGAAGAGCATGGGTTACTGTCTGACGAATACAGGACGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K0M8J0

Antitoxin

Source ID Structure
AlphaFold DB K0MFV7

References