Detailed information of TA system TA137251

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1504858..1505519
• Replicon: chromosome
• Accession: NZ_CP043111
• Organism: Bordetella parapertussis strain I457

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q7WAH5
• Locus tag: FYB06_RS07145
• Protein ID: WP_003812073.1
• Coordinates: 1504858..1505283 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FYB06_RS07150
• Protein ID: WP_003812071.1
• Coordinates: 1505280..1505519 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB06_RS07125	1500672..1501649	+	978	WP_003812083.1	tripartite tricarboxylate transporter substrate binding protein	-
FYB06_RS07130	1501670..1502182	-	513	WP_010928017.1	hypothetical protein	-
FYB06_RS07135	1502681..1504186	+	1506	WP_010928018.1	tripartite tricarboxylate transporter permease	-
FYB06_RS07140	1504284..1504748	-	465	WP_003812075.1	MarR family transcriptional regulator	-
FYB06_RS07145	1504858..1505283	-	426	WP_003812073.1	PIN domain-containing protein	Toxin
FYB06_RS07150	1505280..1505519	-	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
FYB06_RS07155	1505593..1506435	-	843	WP_010928019.1	AraC family transcriptional regulator	-
FYB06_RS07160	1506573..1507118	+	546	WP_010928020.1	peroxidase-related enzyme	-
FYB06_RS07165	1507177..1507689	+	513	WP_003812062.1	redoxin domain-containing protein	-
FYB06_RS07170	1507770..1508003	+	234	WP_033447224.1	DUF2945 domain-containing protein	-
FYB06_RS07175	1508000..1508560	+	561	WP_010928021.1	DUF488 domain-containing protein	-
FYB06_RS07180	1508638..1509684	+	1047	WP_010928022.1	Dyp-type peroxidase	-
FYB06_RS07185	1509681..1510484	+	804	WP_003812055.1	bacteriocin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14811.22 Da
• Isoelectric Point: 6.3704

>T137251 WP_003812073.1 NZ_CP043111:c1505283-1504858 [Bordetella parapertussis]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRVLPLFMGHVLPFDT
AAADAYAAVMMRAAAAGHALCAIDGCIAAIATAHGLAIATRHPARFEAAGLAAVDPWHAAA

Nucleotide

• Length: 426 bp

>T137251 NZ_CP056622:c4358488-4358204 [Citrobacter freundii]
ATGACTTATGAACTGGAATTCGACCCGAGAGCCTTAAAAGAGTGGCATAAACTGGGTGATACGGTGAAGGCTCAGTTTAA
GAAGAAGTTGGCCGACGTGTTGTTGAACCCCAGAATTGACTCTGCCCGTTTAAACGGCCTTCCAGATTGCTATAAAATTA
AGCTTAAATCGTCCGGCTATCGTCTGGTGTACCAGGTTCGGGATGAGGTTGTGACCGTGTTTGTTGTCGCGGTCGGCAAA
CGAGAACATTCGGCCGTTTATCTCGATGCAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT137251 WP_003812071.1 NZ_CP043111:c1505519-1505280 [Bordetella parapertussis]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT137251 NZ_CP056622:c4358720-4358478 [Citrobacter freundii]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCTGTGCGATTACTGTTTCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACCGTTAGCGACA
GCGAAGATACACTGATTCAGACAGTCCGGGAGAGGCTGGCCAGCCCGCAAAAAGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Structures

Toxin

• AlphaFold DB: Q7WAH5