Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpA-brnA/BrnT_toxin-BrnA
Location 2091443..2091974 Replicon chromosome
Accession NZ_CP043110
Organism Bordetella parapertussis strain I458

Toxin (Protein)


Gene name shpA Uniprot ID K0MH61
Locus tag FYB07_RS09985 Protein ID WP_003812626.1
Coordinates 2091708..2091974 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID K0MF02
Locus tag FYB07_RS09980 Protein ID WP_003816743.1
Coordinates 2091443..2091721 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYB07_RS09950 2086873..2087967 + 1095 WP_003812637.1 TRAP transporter substrate-binding protein -
FYB07_RS09955 2088179..2088808 + 630 WP_010928293.1 TRAP transporter small permease subunit -
FYB07_RS09960 2088811..2090478 + 1668 WP_010928294.1 TRAP transporter large permease subunit -
FYB07_RS09965 2090493..2091149 + 657 WP_010928295.1 phosphoribosylanthranilate isomerase -
FYB07_RS09980 2091443..2091721 - 279 WP_003816743.1 BrnA antitoxin family protein Antitoxin
FYB07_RS09985 2091708..2091974 - 267 WP_003812626.1 BrnT family toxin Toxin
FYB07_RS09990 2092205..2093746 - 1542 WP_010928296.1 M81 family metallopeptidase -
FYB07_RS09995 2093808..2094686 - 879 WP_041937387.1 tripartite tricarboxylate transporter substrate binding protein -
FYB07_RS10000 2095083..2095715 + 633 WP_003812619.1 PAS domain-containing protein -
FYB07_RS10005 2095826..2096536 + 711 WP_003812617.1 aquaporin Z -
FYB07_RS10010 2096575..2096847 - 273 WP_003812615.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-81)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(12-86)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10037.47 Da        Isoelectric Point: 7.9923

>T137247 WP_003812626.1 NZ_CP043110:c2091974-2091708 [Bordetella parapertussis]
MDITYDPAKNDKNIADRGLSFELVCGFEWASALVVEDTRQVYAETRYQALGKIDGRLHMVVFTVRGESLRIISLRKANAR
EVARYEKA

Download         Length: 267 bp

>T137247 NZ_CP043110:c2091974-2091708 [Bordetella parapertussis]
ATGGATATCACCTACGACCCCGCCAAGAACGACAAGAACATTGCCGATCGCGGCCTGTCGTTCGAGTTGGTGTGTGGCTT
CGAGTGGGCCAGCGCGCTGGTGGTTGAGGATACCCGCCAGGTCTACGCCGAAACGCGCTATCAGGCGCTGGGCAAAATCG
ATGGCCGGCTCCATATGGTGGTATTCACGGTGCGCGGCGAGTCGCTGCGCATCATCAGCCTGCGTAAGGCAAATGCTCGT
GAGGTAGCTCGTTATGAAAAAGCCTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10412.89 Da        Isoelectric Point: 10.5548

>AT137247 WP_003816743.1 NZ_CP043110:c2091721-2091443 [Bordetella parapertussis]
MKKPDPEKIDRDNPEWTDAEFRRAKPAAEVLPESVHAMLGIRRRGPQKTPTKQVVTIRLSPDVVEAFKASGTGWQTRVDA
ALRDWLKTHQPG

Download         Length: 279 bp

>AT137247 NZ_CP056622:c2036357-2036214 [Citrobacter freundii]
CACATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAAGTTACCCTGCCATTTAAGAATAGATGACAGCGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K0MH61

Antitoxin

Source ID Structure
AlphaFold DB K0MF02

References