Detailed information of TA system TA137237

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpA-brnA/BrnT_toxin-BrnA
• Location: 2091506..2092037
• Replicon: chromosome
• Accession: NZ_CP043108
• Organism: Bordetella parapertussis strain I962

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: K0MH61
• Locus tag: FYB11_RS09985
• Protein ID: WP_003812626.1
• Coordinates: 2091771..2092037 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: K0MF02
• Locus tag: FYB11_RS09980
• Protein ID: WP_003816743.1
• Coordinates: 2091506..2091784 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB11_RS09950	2086936..2088030	+	1095	WP_003812637.1	TRAP transporter substrate-binding protein	-
FYB11_RS09955	2088242..2088871	+	630	WP_010928293.1	TRAP transporter small permease subunit	-
FYB11_RS09960	2088874..2090541	+	1668	WP_010928294.1	TRAP transporter large permease subunit	-
FYB11_RS09965	2090556..2091212	+	657	WP_010928295.1	phosphoribosylanthranilate isomerase	-
FYB11_RS09980	2091506..2091784	-	279	WP_003816743.1	BrnA antitoxin family protein	Antitoxin
FYB11_RS09985	2091771..2092037	-	267	WP_003812626.1	BrnT family toxin	Toxin
FYB11_RS09990	2092268..2093809	-	1542	WP_010928296.1	M81 family metallopeptidase	-
FYB11_RS09995	2093871..2094749	-	879	WP_041937387.1	tripartite tricarboxylate transporter substrate binding protein	-
FYB11_RS10000	2095146..2095778	+	633	WP_003812619.1	PAS domain-containing protein	-
FYB11_RS10005	2095889..2096599	+	711	WP_003812617.1	aquaporin Z	-
FYB11_RS10010	2096638..2096910	-	273	WP_003812615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-81)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (12-86)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10037.47 Da
• Isoelectric Point: 7.9923

>T137237 WP_003812626.1 NZ_CP043108:c2092037-2091771 [Bordetella parapertussis]
MDITYDPAKNDKNIADRGLSFELVCGFEWASALVVEDTRQVYAETRYQALGKIDGRLHMVVFTVRGESLRIISLRKANAR
EVARYEKA

Nucleotide

• Length: 267 bp

>T137237 NZ_CP043108:c2092037-2091771 [Bordetella parapertussis]
ATGGATATCACCTACGACCCCGCCAAGAACGACAAGAACATTGCCGATCGCGGCCTGTCGTTCGAGTTGGTGTGTGGCTT
CGAGTGGGCCAGCGCGCTGGTGGTTGAGGATACCCGCCAGGTCTACGCCGAAACGCGCTATCAGGCGCTGGGCAAAATCG
ATGGCCGGCTCCATATGGTGGTATTCACGGTGCGCGGCGAGTCGCTGCGCATCATCAGCCTGCGTAAGGCAAATGCTCGT
GAGGTAGCTCGTTATGAAAAAGCCTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10412.89 Da
• Isoelectric Point: 10.5548

>AT137237 WP_003816743.1 NZ_CP043108:c2091784-2091506 [Bordetella parapertussis]
MKKPDPEKIDRDNPEWTDAEFRRAKPAAEVLPESVHAMLGIRRRGPQKTPTKQVVTIRLSPDVVEAFKASGTGWQTRVDA
ALRDWLKTHQPG

Nucleotide

• Length: 279 bp

>AT137237 NZ_CP056597:3590611-3590985 [Citrobacter freundii]
ATGGACGAGTACTCACCCAAACGGCATGATATCGCGCAGCTTAAATTTCTCTGCGAAACCTTGTATCATGACTGTCTTGC
AAACCTTGAACAAAGCAACCATGGCTGGGTTAATGACCCGACTTCAGCAACCAGCCTGCAGCTCAACGAACTGATAGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAGGACAATAAGCTGATTGCGCAGATTGATGAATACCTG
GATGACACTTTTATGTTGTTCAGCAATTATGGTATTAATACGCAGGATTTGCAGAAATGGCGAAAGTCCGGAAATCGACT
GTTTCGCTGTTTTGTCAATGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Structures

Toxin

• AlphaFold DB: K0MH61

Antitoxin

• AlphaFold DB: K0MF02