Detailed information of TA system TA137232

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2441884..2442478
• Replicon: chromosome
• Accession: NZ_CP043107
• Organism: Bordetella parapertussis strain J069

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: K0M8J0
• Locus tag: FYB12_RS11505
• Protein ID: WP_010928352.1
• Coordinates: 2441884..2442066 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: K0MFV7
• Locus tag: FYB12_RS11510
• Protein ID: WP_010928351.1
• Coordinates: 2442089..2442478 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB12_RS11485	2436887..2437627	+	741	WP_003809659.1	carbonic anhydrase	-
FYB12_RS11490	2437639..2438994	-	1356	WP_003809657.1	cytochrome c	-
FYB12_RS11495	2439005..2440774	-	1770	WP_010928353.1	GMC family oxidoreductase	-
FYB12_RS11500	2440778..2441476	-	699	WP_003809653.1	gluconate 2-dehydrogenase subunit 3 family protein	-
FYB12_RS11505	2441884..2442066	+	183	WP_010928352.1	type II toxin-antitoxin system HicA family toxin	Toxin
FYB12_RS11510	2442089..2442478	+	390	WP_010928351.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FYB12_RS11520	2442744..2443520	-	777	WP_033448479.1	phosphate ABC transporter ATP-binding protein PstB	-
FYB12_RS11525	2443565..2444422	-	858	WP_003809638.1	phosphate ABC transporter permease PstA	-
FYB12_RS11530	2444444..2445460	-	1017	WP_010928350.1	phosphate ABC transporter permease subunit PstC	-
FYB12_RS11535	2445595..2446635	-	1041	WP_003809635.1	phosphate ABC transporter substrate-binding protein PstS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6750.76 Da
• Isoelectric Point: 11.4018

>T137232 WP_010928352.1 NZ_CP043107:2441884-2442066 [Bordetella parapertussis]
MNSTDLIQQPKADGWYRVHTVGSHHQYKHPTKPGKVTVPHPRKGLPTATQRSILKQAGLR

Nucleotide

• Length: 183 bp

>T137232 NZ_CP056597:c1116976-1116656 [Citrobacter freundii]
ATGCACATTTCAACTGTACCGGCCACGGTGCCGGTTTCGTCACGCCTGTCGCCCGTAATGGTGTGGCAGCAACTGTTAAC
GTATCTGCTGGAGCACCATTACGGCCTCACACTCAACGACACGCCATTCCACGACGACGCAGCCATTGAGGAGCATATCG
ACGCAGGAATCACGCTCGCCGATGCTGTTAATTTTCTGGTGGAACGTTATGAACTGGTACGCATCGACTGCAAAGGATTT
ACATGGCAGGAGCAGACGCCATTCCTGACCGCTACCGATATTCTCAGAGCCAGGCGAGCTATAGGGATAATGAGCACTTA
A

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 14270.92 Da
• Isoelectric Point: 4.3014

>AT137232 WP_010928351.1 NZ_CP043107:2442089-2442478 [Bordetella parapertussis]
MLYPIHVSKDEGSAYGAAFPDFPGCFAAADELQDLPRAAQEAVEAHFYGETERIPAPSAPEAWANDEDYQGGYWMMVDID
LSKVNTKAVRLNISLPENLVHRIDEEAKARRLSRSAFLAMAAEHEMADA

Nucleotide

• Length: 390 bp

>AT137232 NZ_CP043107:2442089-2442478 [Bordetella parapertussis]
ATGCTCTACCCGATCCATGTTTCCAAAGACGAAGGCAGCGCCTACGGGGCCGCCTTCCCTGATTTTCCCGGCTGCTTTGC
AGCCGCCGATGAACTCCAGGACCTCCCCCGCGCGGCGCAGGAAGCCGTTGAGGCGCACTTCTACGGAGAGACCGAGCGTA
TCCCCGCCCCGTCCGCCCCTGAAGCGTGGGCCAACGATGAGGACTATCAAGGCGGCTATTGGATGATGGTCGATATCGAC
CTGTCGAAGGTCAACACGAAGGCCGTGCGGCTCAACATCAGCCTGCCGGAAAACCTGGTTCACCGTATCGACGAGGAAGC
CAAGGCACGACGCCTTTCGCGCTCAGCGTTTCTGGCCATGGCTGCGGAGCACGAAATGGCCGACGCCTAG

Structures

Toxin

• AlphaFold DB: K0M8J0

Antitoxin

• AlphaFold DB: K0MFV7