Detailed information of TA system TA137225

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3381735..3382371
• Replicon: chromosome
• Accession: NZ_CP043104
• Organism: Bordetella parapertussis strain J156

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q7W5Z1
• Locus tag: FYB15_RS15980
• Protein ID: WP_010928914.1
• Coordinates: 3381735..3381917 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q7W5Z0
• Locus tag: FYB15_RS15985
• Protein ID: WP_010928915.1
• Coordinates: 3381979..3382371 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB15_RS15955	3377309..3377986	+	678	WP_010928910.1	HAD-IA family hydrolase	-
FYB15_RS15960	3378204..3379391	+	1188	WP_010928911.1	MFS transporter	-
FYB15_RS15970	3379966..3381186	+	1221	WP_010928912.1	ISL3-like element IS1001 family transposase	-
FYB15_RS15980	3381735..3381917	+	183	WP_010928914.1	type II toxin-antitoxin system HicA family toxin	Toxin
FYB15_RS15985	3381979..3382371	+	393	WP_010928915.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FYB15_RS15990	3382644..3383553	-	910	Protein_3139	LysR family transcriptional regulator	-
FYB15_RS15995	3383678..3384652	+	975	WP_010928916.1	tripartite tricarboxylate transporter substrate binding protein	-
FYB15_RS16000	3384687..3385046	+	360	WP_010928917.1	hypothetical protein	-
FYB15_RS16005	3385113..3386285	+	1173	WP_010928918.1	thiolase domain-containing protein	-
FYB15_RS16010	3386289..3386715	+	427	Protein_3143	OB-fold domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3379966..3381186	1220

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6572.69 Da
• Isoelectric Point: 10.9062

>T137225 WP_010928914.1 NZ_CP043104:3381735-3381917 [Bordetella parapertussis]
MDGKELIKQLERSGWTLRSVKGSHHVFAHPDRPGHISVPHPKKDLGIGLLNSILKAAGLK

Nucleotide

• Length: 183 bp

>T137225 NZ_CP056595:c4261694-4261365 [Citrobacter freundii]
ATGAAAACTCTACCTGCAACAAATCCGCAGGCGGCGAATCTATGTCTGTCGCCCGTGGCTGTCTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACGACATTCAGTGATGAAACGGTAATTCAGAAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAGGGGATTC
GACTGGCAAGAACAGTCCCCATATCTGCGGGCAGTCGATATTCTGCGGGCTCGACAGACAACTGGTTTATTGAATAGCGC
GGCACGGTGA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 14058.82 Da
• Isoelectric Point: 4.2876

>AT137225 WP_010928915.1 NZ_CP043104:3381979-3382371 [Bordetella parapertussis]
VKYPIAIEPGSDTRAWGVVVPDLPGCFSAADEGIDQAIENAKEAIELWIETAIDSGAPIPAATNIANHQANPEFANWIWA
IADVDPAVLDETVERVNITIPRRILKRLDDRARAAGESRSSYIAHLAMTA

Nucleotide

• Length: 393 bp

>AT137225 NZ_CP043104:3381979-3382371 [Bordetella parapertussis]
GTGAAATATCCCATTGCCATTGAACCCGGCAGCGACACGCGCGCCTGGGGAGTCGTTGTTCCTGATCTGCCCGGCTGCTT
TTCCGCAGCGGACGAAGGGATTGATCAAGCAATCGAGAACGCCAAGGAAGCCATTGAGTTGTGGATTGAAACGGCCATCG
ACTCCGGCGCCCCCATTCCTGCGGCAACCAACATAGCCAATCATCAGGCCAATCCTGAGTTCGCCAACTGGATTTGGGCG
ATTGCTGATGTCGATCCTGCAGTCTTGGATGAAACTGTCGAGCGCGTGAACATCACAATCCCGCGCCGAATTCTCAAGCG
CCTGGATGATCGCGCCCGCGCCGCCGGCGAAAGCCGGAGCAGCTACATCGCACATCTCGCCATGACTGCCTGA

Structures

Toxin

• AlphaFold DB: Q7W5Z1

Antitoxin

• AlphaFold DB: Q7W5Z0