Detailed information of TA system TA137223

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2441885..2442479
• Replicon: chromosome
• Accession: NZ_CP043104
• Organism: Bordetella parapertussis strain J156

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: K0M8J0
• Locus tag: FYB15_RS11505
• Protein ID: WP_010928352.1
• Coordinates: 2441885..2442067 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: K0MFV7
• Locus tag: FYB15_RS11510
• Protein ID: WP_010928351.1
• Coordinates: 2442090..2442479 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB15_RS11485	2436888..2437628	+	741	WP_003809659.1	carbonic anhydrase	-
FYB15_RS11490	2437640..2438995	-	1356	WP_003809657.1	cytochrome c	-
FYB15_RS11495	2439006..2440775	-	1770	WP_010928353.1	GMC family oxidoreductase	-
FYB15_RS11500	2440779..2441477	-	699	WP_003809653.1	gluconate 2-dehydrogenase subunit 3 family protein	-
FYB15_RS11505	2441885..2442067	+	183	WP_010928352.1	type II toxin-antitoxin system HicA family toxin	Toxin
FYB15_RS11510	2442090..2442479	+	390	WP_010928351.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FYB15_RS11520	2442745..2443521	-	777	WP_033448479.1	phosphate ABC transporter ATP-binding protein PstB	-
FYB15_RS11525	2443566..2444423	-	858	WP_003809638.1	phosphate ABC transporter permease PstA	-
FYB15_RS11530	2444445..2445461	-	1017	WP_010928350.1	phosphate ABC transporter permease subunit PstC	-
FYB15_RS11535	2445596..2446636	-	1041	WP_003809635.1	phosphate ABC transporter substrate-binding protein PstS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6750.76 Da
• Isoelectric Point: 11.4018

>T137223 WP_010928352.1 NZ_CP043104:2441885-2442067 [Bordetella parapertussis]
MNSTDLIQQPKADGWYRVHTVGSHHQYKHPTKPGKVTVPHPRKGLPTATQRSILKQAGLR

Nucleotide

• Length: 183 bp

>T137223 NZ_CP056595:3601753-3601971 [Citrobacter freundii]
ATGTCCGATAAACCATTAACTAAAACAGATTATTTGATGCGCCTGCGACGTTGCCAGACAATTGATACGCTAGAGCGCGT
TATTGAAAAAAATAAATATGAATTGTCCGACAACGAACTGGCTGTATTTTACTCAGCAGCAGATCATCGCCTTGCTGAAT
TGACCATGAATAAGCTTTACGACAAGATTCCAACTTCTGTTTGGAAATTCATTCGCTAA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 14270.92 Da
• Isoelectric Point: 4.3014

>AT137223 WP_010928351.1 NZ_CP043104:2442090-2442479 [Bordetella parapertussis]
MLYPIHVSKDEGSAYGAAFPDFPGCFAAADELQDLPRAAQEAVEAHFYGETERIPAPSAPEAWANDEDYQGGYWMMVDID
LSKVNTKAVRLNISLPENLVHRIDEEAKARRLSRSAFLAMAAEHEMADA

Nucleotide

• Length: 390 bp

>AT137223 NZ_CP056595:3601351-3601725 [Citrobacter freundii]
ATGGATGAATACTCACCCAAAAGACATGATATCGCGCAGCTTAAATTTCTCTGCGAAACTCTGTATCATGACTGTCTTGC
AAACCTTGAACAAAGTAACCATGGCTGGGTTAATGACCCTACCTCTGCAACCAGCTTGCAGCTCAATGAACTGATAGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAGGACAATAAGCTGATCGCGCAGATAGATGAATACCTG
GATGACACTTTTATGTTGTTCAGCAGTTATGGTATTAATACGCAGGATCTGCAGAAATGGCGGAAGTCAGGTAATCGACT
GTTTCGCTGTTTTGTCAATGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Structures

Toxin

• AlphaFold DB: K0M8J0

Antitoxin

• AlphaFold DB: K0MFV7