Detailed information of TA system TA137216

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 3162639..3163300
• Replicon: chromosome
• Accession: NZ_CP043102
• Organism: Bordetella parapertussis strain J166

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q7WAH5
• Locus tag: FYB17_RS14975
• Protein ID: WP_003812073.1
• Coordinates: 3162875..3163300 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FYB17_RS14970
• Protein ID: WP_003812071.1
• Coordinates: 3162639..3162878 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB17_RS14935	3157674..3158477	-	804	WP_003812055.1	bacteriocin family protein	-
FYB17_RS14940	3158474..3159520	-	1047	WP_010928022.1	Dyp-type peroxidase	-
FYB17_RS14945	3159598..3160158	-	561	WP_010928021.1	DUF488 domain-containing protein	-
FYB17_RS14950	3160155..3160388	-	234	WP_033447224.1	DUF2945 domain-containing protein	-
FYB17_RS14955	3160469..3160981	-	513	WP_003812062.1	redoxin domain-containing protein	-
FYB17_RS14960	3161040..3161585	-	546	WP_010928020.1	peroxidase-related enzyme	-
FYB17_RS14965	3161723..3162565	+	843	WP_010928019.1	AraC family transcriptional regulator	-
FYB17_RS14970	3162639..3162878	+	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
FYB17_RS14975	3162875..3163300	+	426	WP_003812073.1	PIN domain-containing protein	Toxin
FYB17_RS14980	3163410..3163874	+	465	WP_003812075.1	MarR family transcriptional regulator	-
FYB17_RS14985	3163972..3165477	-	1506	WP_010928018.1	tripartite tricarboxylate transporter permease	-
FYB17_RS14990	3165976..3166488	+	513	WP_010928017.1	hypothetical protein	-
FYB17_RS14995	3166509..3167486	-	978	WP_003812083.1	tripartite tricarboxylate transporter substrate binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14811.22 Da
• Isoelectric Point: 6.3704

>T137216 WP_003812073.1 NZ_CP043102:3162875-3163300 [Bordetella parapertussis]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRVLPLFMGHVLPFDT
AAADAYAAVMMRAAAAGHALCAIDGCIAAIATAHGLAIATRHPARFEAAGLAAVDPWHAAA

Nucleotide

• Length: 426 bp

>T137216 NZ_CP056592:c4258999-4258658 [Citrobacter freundii]
ATGAAACCTCAATCTGCAGCAACTTCGCGGGCGGTAAAACCCTGCCTGTCACCCGTGGCTATCTGGCAAATTCTACTGAC
ACGCCTGCTGGAACAACACTACGGCCTGACCCTGAACGACACGCCGTTCAGGGATGAATCCGTTATACAGGAACATATCG
ATGCAGGTATCACGCTGGCCAATGCCGTTAACTTTCTGGTGGAAAAATACGAGCTTGTTCGTATCGATCGCAGAAGGTTT
AGTTGGCAGGAACAATCACCTTATCTTCGGGCAGCAGATATTCTGCGAGCACGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGGTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT137216 WP_003812071.1 NZ_CP043102:3162639-3162878 [Bordetella parapertussis]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT137216 NZ_CP056592:c4259337-4259020 [Citrobacter freundii]
ATGAGCAACATCACTTGGGGCTTGCAGCGCGATATCACGCCGCGCCTGGGAACACGTCTGGTGCAGGAGGGCAACCGGCT
GCACTACCTAGCTGACCGGGCCAGTATCACCGGTAAGTTCAGTGACGCCGAATGCCAGAAGCTGGATGAAACATTCCCGC
ACTTTATCAGCCAGATGGAATCGATGCTGACCTCCGGTGAACTGAATCCCCTACACGTTCATTGCGTCACCCTGTACCAC
ACCGGTTTTACCTGCGAAGCCGACACCCTCGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTAAGCGCTAA

Structures

Toxin

• AlphaFold DB: Q7WAH5