Detailed information of TA system TA137212

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3382835..3383510
• Replicon: chromosome
• Accession: NZ_CP043100
• Organism: Bordetella parapertussis strain J216

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FYB21_RS15915
• Protein ID: WP_203114049.1
• Coordinates: 3382835..3383056 (+)
• Length: 74 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q7W5Z0
• Locus tag: FYB21_RS15920
• Protein ID: WP_010928915.1
• Coordinates: 3383118..3383510 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB21_RS15895	3378448..3379125	+	678	WP_010928910.1	HAD-IA family hydrolase	-
FYB21_RS15900	3379343..3380530	+	1188	WP_010928911.1	MFS transporter	-
FYB21_RS15910	3381105..3382325	+	1221	WP_010928912.1	ISL3-like element IS1001 family transposase	-
FYB21_RS15915	3382835..3383056	+	222	WP_203114049.1	type II toxin-antitoxin system HicA family toxin	Toxin
FYB21_RS15920	3383118..3383510	+	393	WP_010928915.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FYB21_RS15925	3383783..3384692	-	910	Protein_3137	LysR family transcriptional regulator	-
FYB21_RS15930	3384817..3385791	+	975	WP_010928916.1	tripartite tricarboxylate transporter substrate binding protein	-
FYB21_RS15935	3385826..3386185	+	360	WP_010928917.1	hypothetical protein	-
FYB21_RS15940	3386252..3387424	+	1173	WP_010928918.1	thiolase domain-containing protein	-
FYB21_RS15945	3387428..3387854	+	427	Protein_3141	OB-fold domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3381105..3382325	1220

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (16-72)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 74 a.a.
• Molecular weight: 8045.32 Da
• Isoelectric Point: 10.2138

>T137212 WP_203114049.1 NZ_CP043100:3382835-3383056 [Bordetella parapertussis]
MCTIHIESVYSTHTDGKELIKQLERSGWTLRSVKGSHHVFAHPDRPGHISVPHPKKDLGIGLLNSILKAAGLK

Nucleotide

• Length: 222 bp

>T137212 NZ_CP043100:3382835-3383056 [Bordetella parapertussis]
ATGTGTACTATACACATTGAAAGTGTGTATAGTACACACACGGACGGCAAAGAACTGATCAAGCAGCTTGAGCGGTCCGG
GTGGACACTGCGGAGCGTTAAGGGCTCCCACCACGTTTTCGCCCACCCAGACCGCCCCGGACATATCAGCGTCCCTCACC
CTAAAAAGGATCTCGGCATCGGACTACTAAACAGCATCCTCAAAGCAGCTGGTTTGAAGTGA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 14058.82 Da
• Isoelectric Point: 4.2876

>AT137212 WP_010928915.1 NZ_CP043100:3383118-3383510 [Bordetella parapertussis]
VKYPIAIEPGSDTRAWGVVVPDLPGCFSAADEGIDQAIENAKEAIELWIETAIDSGAPIPAATNIANHQANPEFANWIWA
IADVDPAVLDETVERVNITIPRRILKRLDDRARAAGESRSSYIAHLAMTA

Nucleotide

• Length: 393 bp

>AT137212 NZ_CP056592:c1336146-1335772 [Citrobacter freundii]
ATGGATGAATACTCACCCAAAAGACATGATATCGCGCAGCTTAAATTTCTCTGCGAAACTCTGTATCATGACTGTCTTGC
AAACCTTGAACAAAGTAACCATGGCTGGGTTAATGACCCTACCTCTGCAACCAGCTTGCAGCTCAATGAACTGATAGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAGGACAATAAGCTGATCGCGCAGATAGATGAATACCTG
GATGACACTTTTATGTTGTTCAGCAGTTATGGTATTAATACGCAGGATCTGCAGAAATGGCGGAAGTCAGGTAATCGACT
GTTTCGCTGTTTTGTCAATGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Structures

Antitoxin

• AlphaFold DB: Q7W5Z0