Detailed information of TA system TA137210

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2226948..2227542
• Replicon: chromosome
• Accession: NZ_CP043100
• Organism: Bordetella parapertussis strain J216

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: K0M8J0
• Locus tag: FYB21_RS10560
• Protein ID: WP_010928352.1
• Coordinates: 2227360..2227542 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: K0MFV7
• Locus tag: FYB21_RS10555
• Protein ID: WP_010928351.1
• Coordinates: 2226948..2227337 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB21_RS10530	2222791..2223831	+	1041	WP_003809635.1	phosphate ABC transporter substrate-binding protein PstS	-
FYB21_RS10535	2223966..2224982	+	1017	WP_010928350.1	phosphate ABC transporter permease subunit PstC	-
FYB21_RS10540	2225004..2225861	+	858	WP_003809638.1	phosphate ABC transporter permease PstA	-
FYB21_RS10545	2225906..2226682	+	777	WP_033448479.1	phosphate ABC transporter ATP-binding protein PstB	-
FYB21_RS10555	2226948..2227337	-	390	WP_010928351.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FYB21_RS10560	2227360..2227542	-	183	WP_010928352.1	type II toxin-antitoxin system HicA family toxin	Toxin
FYB21_RS10565	2227950..2228648	+	699	WP_003809653.1	gluconate 2-dehydrogenase subunit 3 family protein	-
FYB21_RS10570	2228652..2230421	+	1770	WP_010928353.1	GMC family oxidoreductase	-
FYB21_RS10575	2230432..2231787	+	1356	WP_003809657.1	cytochrome c	-
FYB21_RS10580	2231799..2232539	-	741	WP_003809659.1	carbonic anhydrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6750.76 Da
• Isoelectric Point: 11.4018

>T137210 WP_010928352.1 NZ_CP043100:c2227542-2227360 [Bordetella parapertussis]
MNSTDLIQQPKADGWYRVHTVGSHHQYKHPTKPGKVTVPHPRKGLPTATQRSILKQAGLR

Nucleotide

• Length: 183 bp

>T137210 NZ_CP056592:381004-381363 [Citrobacter freundii]
ATGACGAAACCACTTTACTGGGTTGGGCATGCCTGGAAAGATCTACAGGGAATGCCAGAACATGTTCGGGATACGTTTGG
GTTTGCTCTTTGGCTTGCGCAGCAGGGTAAACAGCATTCACAGACTAAACCATTAAAAGGATTTGGTGGCGCGGGGGTTC
TGGAAGTCGTTGAGGATTATCACGGCAACACCTGGCGGGCGGTTTACACCATCCAGTTGAAAAATGCGGTTTATGTTCTC
CATGTTTTTCAGAAGAAGTCCGTTGCCGGGAAGGCAACGCCCAAACCTGAAATTGACCTGATTTATCAGCGGATCAAGGC
TGCACAGCGCCATGCGCAGGAGAGTGGATATGTCACATGA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 14270.92 Da
• Isoelectric Point: 4.3014

>AT137210 WP_010928351.1 NZ_CP043100:c2227337-2226948 [Bordetella parapertussis]
MLYPIHVSKDEGSAYGAAFPDFPGCFAAADELQDLPRAAQEAVEAHFYGETERIPAPSAPEAWANDEDYQGGYWMMVDID
LSKVNTKAVRLNISLPENLVHRIDEEAKARRLSRSAFLAMAAEHEMADA

Nucleotide

• Length: 390 bp

>AT137210 NZ_CP056592:381353-381670 [Citrobacter freundii]
ATGTCACATGAAGTTGAAGCCAGTAGCGGAAATGTTTACGCCGATTTAGGCGTGTATGACGCAGAACAGATGCAGTTGAA
AGCGCAACTGGCAATGGTGATTGGTGAGATTTTGCAACGCAAAGGGTTAACGCAGCAGCAGTCCGCGCAGCTACTGGGAA
TGACGCAGCCTAAACTTTCCAACCTGCTACGTGGTCAGTTTCGTGGTATCAGTGAAGCAAAGATGCTCGAATGCCTGGTG
AGGCTGGGCCGTGATGTAGAGATTGTTGTCGGGAAAGAGGGCAATATGTCAGGAAAGCTGAAAGTGAAATTTGGCTGA

Structures

Toxin

• AlphaFold DB: K0M8J0

Antitoxin

• AlphaFold DB: K0MFV7