Detailed information of TA system TA137208

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1506326..1506987
• Replicon: chromosome
• Accession: NZ_CP043100
• Organism: Bordetella parapertussis strain J216

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q7WAH5
• Locus tag: FYB21_RS07110
• Protein ID: WP_003812073.1
• Coordinates: 1506326..1506751 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FYB21_RS07115
• Protein ID: WP_003812071.1
• Coordinates: 1506748..1506987 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB21_RS07090	1502139..1503116	+	978	WP_003812083.1	tripartite tricarboxylate transporter substrate binding protein	-
FYB21_RS07095	1503137..1503649	-	513	WP_010928017.1	hypothetical protein	-
FYB21_RS07100	1504148..1505653	+	1506	WP_010928018.1	tripartite tricarboxylate transporter permease	-
FYB21_RS07105	1505752..1506216	-	465	WP_003812075.1	MarR family transcriptional regulator	-
FYB21_RS07110	1506326..1506751	-	426	WP_003812073.1	PIN domain-containing protein	Toxin
FYB21_RS07115	1506748..1506987	-	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
FYB21_RS07120	1507061..1507903	-	843	WP_010928019.1	AraC family transcriptional regulator	-
FYB21_RS07125	1508041..1508586	+	546	WP_010928020.1	peroxidase-related enzyme	-
FYB21_RS07130	1508645..1509157	+	513	WP_003812062.1	redoxin domain-containing protein	-
FYB21_RS07135	1509238..1509471	+	234	WP_033447224.1	DUF2945 domain-containing protein	-
FYB21_RS07140	1509468..1510028	+	561	WP_010928021.1	DUF488 domain-containing protein	-
FYB21_RS07145	1510106..1511152	+	1047	WP_010928022.1	Dyp-type peroxidase	-
FYB21_RS07150	1511149..1511952	+	804	WP_003812055.1	bacteriocin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14811.22 Da
• Isoelectric Point: 6.3704

>T137208 WP_003812073.1 NZ_CP043100:c1506751-1506326 [Bordetella parapertussis]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRVLPLFMGHVLPFDT
AAADAYAAVMMRAAAAGHALCAIDGCIAAIATAHGLAIATRHPARFEAAGLAAVDPWHAAA

Nucleotide

• Length: 426 bp

>T137208 NZ_CP043100:c1506751-1506326 [Bordetella parapertussis]
ATGATCCTGCTCGACACCGACGTGCTGCTCGAGCCGCTGCGGCCGGCCCCCGACCCGGCCGTCGCGGCATGGCTGGATGC
CCAGCACGTCGAAACCCTGTACCTGGCCGCGCCCGGCGCGGCCGAAATCCAGCTCGGGCTGGCCCGCCTGCCGCGCGGCA
AGCGGGCCGAGGCCTTGCGCCACGAATTCGAGCGGCGCGTCCTGCCGCTGTTCATGGGCCATGTCCTGCCCTTCGACACG
GCCGCGGCCGATGCCTACGCCGCCGTCATGATGCGGGCCGCGGCGGCGGGCCATGCGCTGTGCGCAATCGATGGTTGCAT
CGCCGCCATCGCCACCGCGCACGGCCTGGCCATCGCCACGCGCCATCCGGCCAGGTTCGAGGCGGCCGGGCTCGCCGCCG
TCGATCCCTGGCACGCCGCCGCTTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT137208 WP_003812071.1 NZ_CP043100:c1506987-1506748 [Bordetella parapertussis]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT137208 NZ_CP043100:c1506987-1506748 [Bordetella parapertussis]
GTGTCTTCGATTACGGTAAGAAATGTTCCCGAGGAAGTGCATCGCGCCTTGCGCGTACGCGCGGCCACGCATGGGCGCAG
CACCGAGGCCGAGATCCGCGCCATCCTGGAAAACGCCGTGCTGCCCGATGGCCGCGTCAAGCTGGGCACCCTGCTCAGCC
ACATCGGCCGCGGCGCGCGCGGCATGGACCTGACCATCGAGCGCAATCCGGCGCCCGCTCGCCCGGCCAGCTTCGAATGA

Structures

Toxin

• AlphaFold DB: Q7WAH5