Detailed information of TA system TA137196

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1393429..1394023
• Replicon: chromosome
• Accession: NZ_CP043096
• Organism: Bordetella parapertussis strain J220

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: K0M8J0
• Locus tag: FYB25_RS06600
• Protein ID: WP_010928352.1
• Coordinates: 1393841..1394023 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: K0MFV7
• Locus tag: FYB25_RS06595
• Protein ID: WP_010928351.1
• Coordinates: 1393429..1393818 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB25_RS06570 (FYB25_06540)	1389272..1390312	+	1041	WP_003809635.1	phosphate ABC transporter substrate-binding protein PstS	-
FYB25_RS06575 (FYB25_06545)	1390447..1391463	+	1017	WP_010928350.1	phosphate ABC transporter permease subunit PstC	-
FYB25_RS06580 (FYB25_06550)	1391485..1392342	+	858	WP_003809638.1	phosphate ABC transporter permease PstA	-
FYB25_RS06585 (FYB25_06555)	1392387..1393163	+	777	WP_033448479.1	phosphate ABC transporter ATP-binding protein PstB	-
FYB25_RS06595 (FYB25_06565)	1393429..1393818	-	390	WP_010928351.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FYB25_RS06600 (FYB25_06570)	1393841..1394023	-	183	WP_010928352.1	type II toxin-antitoxin system HicA family toxin	Toxin
FYB25_RS06605 (FYB25_06575)	1394467..1395129	+	663	WP_226376529.1	gluconate 2-dehydrogenase subunit 3 family protein	-
FYB25_RS06610 (FYB25_06580)	1395133..1396902	+	1770	WP_010928353.1	GMC family oxidoreductase	-
FYB25_RS06615 (FYB25_06585)	1396913..1398268	+	1356	WP_003809657.1	cytochrome c	-
FYB25_RS06620 (FYB25_06590)	1398280..1399020	-	741	WP_003809659.1	carbonic anhydrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6750.76 Da
• Isoelectric Point: 11.4018

>T137196 WP_010928352.1 NZ_CP043096:c1394023-1393841 [Bordetella parapertussis]
MNSTDLIQQPKADGWYRVHTVGSHHQYKHPTKPGKVTVPHPRKGLPTATQRSILKQAGLR

Nucleotide

• Length: 183 bp

>T137196 NZ_CP043096:c1394023-1393841 [Bordetella parapertussis]
ATGAACAGCACAGACCTGATCCAGCAACCGAAGGCCGACGGCTGGTATCGCGTGCATACCGTGGGTTCACACCACCAGTA
CAAGCACCCGACCAAGCCCGGCAAGGTCACCGTGCCGCATCCCAGGAAGGGCCTGCCGACAGCGACACAGCGCAGCATCC
TTAAGCAAGCCGGCCTGCGATAA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 14270.92 Da
• Isoelectric Point: 4.3014

>AT137196 WP_010928351.1 NZ_CP043096:c1393818-1393429 [Bordetella parapertussis]
MLYPIHVSKDEGSAYGAAFPDFPGCFAAADELQDLPRAAQEAVEAHFYGETERIPAPSAPEAWANDEDYQGGYWMMVDID
LSKVNTKAVRLNISLPENLVHRIDEEAKARRLSRSAFLAMAAEHEMADA

Nucleotide

• Length: 390 bp

>AT137196 NZ_CP043096:c1393818-1393429 [Bordetella parapertussis]
ATGCTCTACCCGATCCATGTTTCCAAAGACGAAGGCAGCGCCTACGGGGCCGCCTTCCCTGATTTTCCCGGCTGCTTTGC
AGCCGCCGATGAACTCCAGGACCTCCCCCGCGCGGCGCAGGAAGCCGTTGAGGCGCACTTCTACGGAGAGACCGAGCGTA
TCCCCGCCCCGTCCGCCCCTGAAGCGTGGGCCAACGATGAGGACTATCAAGGCGGCTATTGGATGATGGTCGATATCGAC
CTGTCGAAGGTCAACACGAAGGCCGTGCGGCTCAACATCAGCCTGCCGGAAAACCTGGTTCACCGTATCGACGAGGAAGC
CAAGGCACGACGCCTTTCGCGCTCAGCGTTTCTGGCCATGGCTGCGGAGCACGAAATGGCCGACGCCTAG

Structures

Toxin

• AlphaFold DB: K0M8J0

Antitoxin

• AlphaFold DB: K0MFV7