Detailed information of TA system TA137195

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 672640..673301
• Replicon: chromosome
• Accession: NZ_CP043096
• Organism: Bordetella parapertussis strain J220

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q7WAH5
• Locus tag: FYB25_RS03115
• Protein ID: WP_003812073.1
• Coordinates: 672640..673065 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FYB25_RS03120
• Protein ID: WP_003812071.1
• Coordinates: 673062..673301 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB25_RS03095 (FYB25_03070)	668454..669431	+	978	WP_003812083.1	tripartite tricarboxylate transporter substrate binding protein	-
FYB25_RS03100 (FYB25_03075)	669452..669964	-	513	WP_010928017.1	hypothetical protein	-
FYB25_RS03105 (FYB25_03080)	670463..671968	+	1506	WP_010928018.1	tripartite tricarboxylate transporter permease	-
FYB25_RS03110 (FYB25_03085)	672066..672530	-	465	WP_003812075.1	MarR family transcriptional regulator	-
FYB25_RS03115 (FYB25_03090)	672640..673065	-	426	WP_003812073.1	PIN domain-containing protein	Toxin
FYB25_RS03120 (FYB25_03095)	673062..673301	-	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
FYB25_RS03125 (FYB25_03100)	673375..674217	-	843	WP_010928019.1	AraC family transcriptional regulator	-
FYB25_RS03130 (FYB25_03105)	674355..674900	+	546	WP_010928020.1	peroxidase-related enzyme	-
FYB25_RS03135 (FYB25_03110)	674959..675471	+	513	WP_003812062.1	redoxin domain-containing protein	-
FYB25_RS03140 (FYB25_03115)	675552..675785	+	234	WP_033447224.1	DUF2945 domain-containing protein	-
FYB25_RS03145 (FYB25_03120)	675782..676342	+	561	WP_010928021.1	DUF488 domain-containing protein	-
FYB25_RS03150 (FYB25_03125)	676420..677466	+	1047	WP_010928022.1	Dyp-type peroxidase	-
FYB25_RS03155 (FYB25_03130)	677463..678266	+	804	WP_003812055.1	family 1 encapsulin nanocompartment shell protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14811.22 Da
• Isoelectric Point: 6.3704

>T137195 WP_003812073.1 NZ_CP043096:c673065-672640 [Bordetella parapertussis]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRVLPLFMGHVLPFDT
AAADAYAAVMMRAAAAGHALCAIDGCIAAIATAHGLAIATRHPARFEAAGLAAVDPWHAAA

Nucleotide

• Length: 426 bp

>T137195 NZ_CP043096:c673065-672640 [Bordetella parapertussis]
ATGATCCTGCTCGACACCGACGTGCTGCTCGAGCCGCTGCGGCCGGCCCCCGACCCGGCCGTCGCGGCATGGCTGGATGC
CCAGCACGTCGAAACCCTGTACCTGGCCGCGCCCGGCGCGGCCGAAATCCAGCTCGGGCTGGCCCGCCTGCCGCGCGGCA
AGCGGGCCGAGGCCTTGCGCCACGAATTCGAGCGGCGCGTCCTGCCGCTGTTCATGGGCCATGTCCTGCCCTTCGACACG
GCCGCGGCCGATGCCTACGCCGCCGTCATGATGCGGGCCGCGGCGGCGGGCCATGCGCTGTGCGCAATCGATGGTTGCAT
CGCCGCCATCGCCACCGCGCACGGCCTGGCCATCGCCACGCGCCATCCGGCCAGGTTCGAGGCGGCCGGGCTCGCCGCCG
TCGATCCCTGGCACGCCGCCGCTTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT137195 WP_003812071.1 NZ_CP043096:c673301-673062 [Bordetella parapertussis]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT137195 NZ_CP043096:c673301-673062 [Bordetella parapertussis]
GTGTCTTCGATTACGGTAAGAAATGTTCCCGAGGAAGTGCATCGCGCCTTGCGCGTACGCGCGGCCACGCATGGGCGCAG
CACCGAGGCCGAGATCCGCGCCATCCTGGAAAACGCCGTGCTGCCCGATGGCCGCGTCAAGCTGGGCACCCTGCTCAGCC
ACATCGGCCGCGGCGCGCGCGGCATGGACCTGACCATCGAGCGCAATCCGGCGCCCGCTCGCCCGGCCAGCTTCGAATGA

Structures

Toxin

• AlphaFold DB: Q7WAH5