Detailed information of TA system TA137194

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 453577..454213
• Replicon: chromosome
• Accession: NZ_CP043096
• Organism: Bordetella parapertussis strain J220

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q7W5Z1
• Locus tag: FYB25_RS02105
• Protein ID: WP_010928914.1
• Coordinates: 454031..454213 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q7W5Z0
• Locus tag: FYB25_RS02100
• Protein ID: WP_010928915.1
• Coordinates: 453577..453969 (-)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB25_RS02065 (FYB25_02050)	449233..449659	-	427	Protein_407	OB-fold domain-containing protein	-
FYB25_RS02070 (FYB25_02055)	449663..450835	-	1173	WP_010928918.1	thiolase domain-containing protein	-
FYB25_RS02075 (FYB25_02060)	450902..451261	-	360	WP_010928917.1	hypothetical protein	-
FYB25_RS02080 (FYB25_02065)	451296..452270	-	975	WP_010928916.1	tripartite tricarboxylate transporter substrate binding protein	-
FYB25_RS02085	452323..452493	-	171	WP_226376428.1	hypothetical protein	-
FYB25_RS02090	452467..452538	+	72	Protein_412	LysR family transcriptional regulator	-
FYB25_RS02095 (FYB25_02070)	452576..453304	+	729	WP_226376427.1	LysR family substrate-binding domain-containing protein	-
FYB25_RS02100 (FYB25_02075)	453577..453969	-	393	WP_010928915.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FYB25_RS02105 (FYB25_02080)	454031..454213	-	183	WP_010928914.1	type II toxin-antitoxin system HicA family toxin	Toxin
FYB25_RS02110 (FYB25_02090)	454762..455982	-	1221	WP_010928912.1	ISL3-like element IS1001 family transposase	-
FYB25_RS02120 (FYB25_02100)	456557..457744	-	1188	WP_010928911.1	MFS transporter	-
FYB25_RS02125 (FYB25_02105)	457962..458639	-	678	WP_010928910.1	HAD-IA family hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	454762..455982	1220

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6572.69 Da
• Isoelectric Point: 10.9062

>T137194 WP_010928914.1 NZ_CP043096:c454213-454031 [Bordetella parapertussis]
MDGKELIKQLERSGWTLRSVKGSHHVFAHPDRPGHISVPHPKKDLGIGLLNSILKAAGLK

Nucleotide

• Length: 183 bp

>T137194 NZ_CP056573:883263-883670 [Citrobacter freundii]
GTGGTCCAGTGGCAATCTGATTTACGCGTATCATGGCGCGCGCAGTGGCTTTCACTGCTAATTCATGGGCTGGTCGCGGT
GTTTATTTTATTGATGCCCTGGCCATTGAGCTACACCCCATTATGGCTGGTTTTGCTCTCTCTGGTGGTATTCGATAGCG
TTCGCAGTCAGCGTCGAATCAACGCCTGTCAGGGTGAGATTCGGCTGTTGATGGATGGCCGTCTGCGCTGGCAAGGGCAA
GAGTGGTCTATCGTTAGCGCCCCCTGGATGGTTAAAACAGGCATGATGCTGCGTTTGCGCTCTGATGCCGGAAAACGTCA
ACATTTGTGGCTGGCGGCAGACAGTATGGATGATGCAGAGTGGCGGGATTTACGGCGGTTGATGCTGCAAAAGGCGAAGC
AGAAGTAG

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 14058.82 Da
• Isoelectric Point: 4.2876

>AT137194 WP_010928915.1 NZ_CP043096:c453969-453577 [Bordetella parapertussis]
VKYPIAIEPGSDTRAWGVVVPDLPGCFSAADEGIDQAIENAKEAIELWIETAIDSGAPIPAATNIANHQANPEFANWIWA
IADVDPAVLDETVERVNITIPRRILKRLDDRARAAGESRSSYIAHLAMTA

Nucleotide

• Length: 393 bp

>AT137194 NZ_CP043096:c453969-453577 [Bordetella parapertussis]
GTGAAATATCCCATTGCCATTGAACCCGGCAGCGACACGCGCGCCTGGGGAGTCGTTGTTCCTGATCTGCCCGGCTGCTT
TTCCGCAGCGGACGAAGGGATTGATCAAGCAATCGAGAACGCCAAGGAAGCCATTGAGTTGTGGATTGAAACGGCCATCG
ACTCCGGCGCCCCCATTCCTGCGGCAACCAACATAGCCAATCATCAGGCCAATCCTGAGTTCGCCAACTGGATTTGGGCG
ATTGCTGATGTCGATCCTGCAGTCTTGGATGAAACTGTCGAGCGCGTGAACATCACAATCCCGCGCCGAATTCTCAAGCG
CCTGGATGATCGCGCCCGCGCCGCCGGCGAAAGCCGGAGCAGCTACATCGCACATCTCGCCATGACTGCCTGA

Structures

Toxin

• AlphaFold DB: Q7W5Z1

Antitoxin

• AlphaFold DB: Q7W5Z0