Detailed information of TA system TA137170

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2441908..2442502
• Replicon: chromosome
• Accession: NZ_CP043091
• Organism: Bordetella parapertussis strain J281

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: K0M8J0
• Locus tag: FYB30_RS11505
• Protein ID: WP_010928352.1
• Coordinates: 2441908..2442090 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: K0MFV7
• Locus tag: FYB30_RS11510
• Protein ID: WP_010928351.1
• Coordinates: 2442113..2442502 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB30_RS11485	2436911..2437651	+	741	WP_003809659.1	carbonic anhydrase	-
FYB30_RS11490	2437663..2439018	-	1356	WP_003809657.1	cytochrome c	-
FYB30_RS11495	2439029..2440798	-	1770	WP_010928353.1	GMC family oxidoreductase	-
FYB30_RS11500	2440802..2441500	-	699	WP_003809653.1	gluconate 2-dehydrogenase subunit 3 family protein	-
FYB30_RS11505	2441908..2442090	+	183	WP_010928352.1	type II toxin-antitoxin system HicA family toxin	Toxin
FYB30_RS11510	2442113..2442502	+	390	WP_010928351.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FYB30_RS11520	2442768..2443544	-	777	WP_033448479.1	phosphate ABC transporter ATP-binding protein PstB	-
FYB30_RS11525	2443589..2444446	-	858	WP_003809638.1	phosphate ABC transporter permease PstA	-
FYB30_RS11530	2444468..2445484	-	1017	WP_010928350.1	phosphate ABC transporter permease subunit PstC	-
FYB30_RS11535	2445619..2446659	-	1041	WP_003809635.1	phosphate ABC transporter substrate-binding protein PstS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6750.76 Da
• Isoelectric Point: 11.4018

>T137170 WP_010928352.1 NZ_CP043091:2441908-2442090 [Bordetella parapertussis]
MNSTDLIQQPKADGWYRVHTVGSHHQYKHPTKPGKVTVPHPRKGLPTATQRSILKQAGLR

Nucleotide

• Length: 183 bp

>T137170 NZ_CP043091:2441908-2442090 [Bordetella parapertussis]
ATGAACAGCACAGACCTGATCCAGCAACCGAAGGCCGACGGCTGGTATCGCGTGCATACCGTGGGTTCACACCACCAGTA
CAAGCACCCGACCAAGCCCGGCAAGGTCACCGTGCCGCATCCCAGGAAGGGCCTGCCGACAGCGACACAGCGCAGCATCC
TTAAGCAAGCCGGCCTGCGATAA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 14270.92 Da
• Isoelectric Point: 4.3014

>AT137170 WP_010928351.1 NZ_CP043091:2442113-2442502 [Bordetella parapertussis]
MLYPIHVSKDEGSAYGAAFPDFPGCFAAADELQDLPRAAQEAVEAHFYGETERIPAPSAPEAWANDEDYQGGYWMMVDID
LSKVNTKAVRLNISLPENLVHRIDEEAKARRLSRSAFLAMAAEHEMADA

Nucleotide

• Length: 390 bp

>AT137170 NZ_CP056553:84229-84495 [Enterobacter sp. RHBSTW-00422]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTAGAGATTGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGATTCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Structures

Toxin

• AlphaFold DB: K0M8J0

Antitoxin

• AlphaFold DB: K0MFV7