Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3381725..3382361 Replicon chromosome
Accession NZ_CP043090
Organism Bordetella parapertussis strain J282

Toxin (Protein)


Gene name hicA Uniprot ID Q7W5Z1
Locus tag FYB31_RS15980 Protein ID WP_010928914.1
Coordinates 3381725..3381907 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q7W5Z0
Locus tag FYB31_RS15985 Protein ID WP_010928915.1
Coordinates 3381969..3382361 (+) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYB31_RS15955 3377299..3377976 + 678 WP_010928910.1 HAD-IA family hydrolase -
FYB31_RS15960 3378194..3379381 + 1188 WP_010928911.1 MFS transporter -
FYB31_RS15970 3379956..3381176 + 1221 WP_010928912.1 ISL3-like element IS1001 family transposase -
FYB31_RS15980 3381725..3381907 + 183 WP_010928914.1 type II toxin-antitoxin system HicA family toxin Toxin
FYB31_RS15985 3381969..3382361 + 393 WP_010928915.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FYB31_RS15990 3382634..3383543 - 910 Protein_3139 LysR family transcriptional regulator -
FYB31_RS15995 3383668..3384642 + 975 WP_010928916.1 tripartite tricarboxylate transporter substrate binding protein -
FYB31_RS16000 3384677..3385036 + 360 WP_010928917.1 hypothetical protein -
FYB31_RS16005 3385103..3386275 + 1173 WP_010928918.1 thiolase domain-containing protein -
FYB31_RS16010 3386279..3386705 + 427 Protein_3143 OB-fold domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3379956..3381176 1220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6572.69 Da        Isoelectric Point: 10.9062

>T137168 WP_010928914.1 NZ_CP043090:3381725-3381907 [Bordetella parapertussis]
MDGKELIKQLERSGWTLRSVKGSHHVFAHPDRPGHISVPHPKKDLGIGLLNSILKAAGLK

Download         Length: 183 bp

>T137168 NZ_CP056552:c2959681-2959578 [Enterobacter sp. RHBSTW-00422]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 14058.82 Da        Isoelectric Point: 4.2876

>AT137168 WP_010928915.1 NZ_CP043090:3381969-3382361 [Bordetella parapertussis]
VKYPIAIEPGSDTRAWGVVVPDLPGCFSAADEGIDQAIENAKEAIELWIETAIDSGAPIPAATNIANHQANPEFANWIWA
IADVDPAVLDETVERVNITIPRRILKRLDDRARAAGESRSSYIAHLAMTA

Download         Length: 393 bp

>AT137168 NZ_CP056552:2959564-2959716 [Enterobacter sp. RHBSTW-00422]
GCTTTCAATCAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCG
CTAAAAGTTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q7W5Z1

Antitoxin

Source ID Structure
AlphaFold DB Q7W5Z0

References