Detailed information of TA system TA137166

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpA-brnA/BrnT_toxin-BrnA
• Location: 2576114..2576645
• Replicon: chromosome
• Accession: NZ_CP043090
• Organism: Bordetella parapertussis strain J282

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: K0MH61
• Locus tag: FYB31_RS12140
• Protein ID: WP_003812626.1
• Coordinates: 2576114..2576380 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: K0MF02
• Locus tag: FYB31_RS12145
• Protein ID: WP_003816743.1
• Coordinates: 2576367..2576645 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB31_RS12115	2571241..2571513	+	273	WP_003812615.1	hypothetical protein	-
FYB31_RS12120	2571552..2572262	-	711	WP_003812617.1	aquaporin Z	-
FYB31_RS12125	2572373..2573005	-	633	WP_003812619.1	PAS domain-containing protein	-
FYB31_RS12130	2573402..2574280	+	879	WP_041937387.1	tripartite tricarboxylate transporter substrate binding protein	-
FYB31_RS12135	2574342..2575883	+	1542	WP_010928296.1	M81 family metallopeptidase	-
FYB31_RS12140	2576114..2576380	+	267	WP_003812626.1	BrnT family toxin	Toxin
FYB31_RS12145	2576367..2576645	+	279	WP_003816743.1	BrnA antitoxin family protein	Antitoxin
FYB31_RS12155	2576939..2577595	-	657	WP_010928295.1	phosphoribosylanthranilate isomerase	-
FYB31_RS12160	2577610..2579277	-	1668	WP_010928294.1	TRAP transporter large permease subunit	-
FYB31_RS12165	2579280..2579909	-	630	WP_010928293.1	TRAP transporter small permease subunit	-
FYB31_RS12170	2580121..2581215	-	1095	WP_003812637.1	TRAP transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-81)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (12-86)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10037.47 Da
• Isoelectric Point: 7.9923

>T137166 WP_003812626.1 NZ_CP043090:2576114-2576380 [Bordetella parapertussis]
MDITYDPAKNDKNIADRGLSFELVCGFEWASALVVEDTRQVYAETRYQALGKIDGRLHMVVFTVRGESLRIISLRKANAR
EVARYEKA

Nucleotide

• Length: 267 bp

>T137166 NZ_CP043090:2576114-2576380 [Bordetella parapertussis]
ATGGATATCACCTACGACCCCGCCAAGAACGACAAGAACATTGCCGATCGCGGCCTGTCGTTCGAGTTGGTGTGTGGCTT
CGAGTGGGCCAGCGCGCTGGTGGTTGAGGATACCCGCCAGGTCTACGCCGAAACGCGCTATCAGGCGCTGGGCAAAATCG
ATGGCCGGCTCCATATGGTGGTATTCACGGTGCGCGGCGAGTCGCTGCGCATCATCAGCCTGCGTAAGGCAAATGCTCGT
GAGGTAGCTCGTTATGAAAAAGCCTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10412.89 Da
• Isoelectric Point: 10.5548

>AT137166 WP_003816743.1 NZ_CP043090:2576367-2576645 [Bordetella parapertussis]
MKKPDPEKIDRDNPEWTDAEFRRAKPAAEVLPESVHAMLGIRRRGPQKTPTKQVVTIRLSPDVVEAFKASGTGWQTRVDA
ALRDWLKTHQPG

Nucleotide

• Length: 279 bp

>AT137166 NZ_CP043090:2576367-2576645 [Bordetella parapertussis]
ATGAAAAAGCCTGACCCCGAAAAGATTGACCGCGACAACCCCGAATGGACGGACGCGGAATTTCGGCGGGCCAAGCCGGC
CGCCGAAGTACTGCCCGAGTCGGTGCACGCGATGCTCGGCATTCGTCGCCGTGGGCCTCAAAAGACACCCACCAAACAGG
TCGTCACCATCCGGCTATCGCCTGACGTGGTAGAAGCCTTCAAGGCCTCCGGCACCGGTTGGCAGACTCGCGTGGATGCA
GCCCTGCGGGATTGGCTGAAGACGCACCAGCCTGGCTAG

Structures

Toxin

• AlphaFold DB: K0MH61

Antitoxin

• AlphaFold DB: K0MF02