Detailed information of TA system TA137161

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2225631..2226225
• Replicon: chromosome
• Accession: NZ_CP043089
• Organism: Bordetella parapertussis strain J284

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: K0M8J0
• Locus tag: FYB33_RS10620
• Protein ID: WP_010928352.1
• Coordinates: 2226043..2226225 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: K0MFV7
• Locus tag: FYB33_RS10615
• Protein ID: WP_010928351.1
• Coordinates: 2225631..2226020 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB33_RS10590	2221474..2222514	+	1041	WP_003809635.1	phosphate ABC transporter substrate-binding protein PstS	-
FYB33_RS10595	2222649..2223665	+	1017	WP_010928350.1	phosphate ABC transporter permease subunit PstC	-
FYB33_RS10600	2223687..2224544	+	858	WP_003809638.1	phosphate ABC transporter permease PstA	-
FYB33_RS10605	2224589..2225365	+	777	WP_033448479.1	phosphate ABC transporter ATP-binding protein PstB	-
FYB33_RS10615	2225631..2226020	-	390	WP_010928351.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FYB33_RS10620	2226043..2226225	-	183	WP_010928352.1	type II toxin-antitoxin system HicA family toxin	Toxin
FYB33_RS10625	2226633..2227331	+	699	WP_003809653.1	gluconate 2-dehydrogenase subunit 3 family protein	-
FYB33_RS10630	2227335..2229104	+	1770	WP_010928353.1	GMC family oxidoreductase	-
FYB33_RS10635	2229115..2230470	+	1356	WP_003809657.1	cytochrome c	-
FYB33_RS10640	2230482..2231222	-	741	WP_003809659.1	carbonic anhydrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6750.76 Da
• Isoelectric Point: 11.4018

>T137161 WP_010928352.1 NZ_CP043089:c2226225-2226043 [Bordetella parapertussis]
MNSTDLIQQPKADGWYRVHTVGSHHQYKHPTKPGKVTVPHPRKGLPTATQRSILKQAGLR

Nucleotide

• Length: 183 bp

>T137161 NZ_CP043089:c2226225-2226043 [Bordetella parapertussis]
ATGAACAGCACAGACCTGATCCAGCAACCGAAGGCCGACGGCTGGTATCGCGTGCATACCGTGGGTTCACACCACCAGTA
CAAGCACCCGACCAAGCCCGGCAAGGTCACCGTGCCGCATCCCAGGAAGGGCCTGCCGACAGCGACACAGCGCAGCATCC
TTAAGCAAGCCGGCCTGCGATAA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 14270.92 Da
• Isoelectric Point: 4.3014

>AT137161 WP_010928351.1 NZ_CP043089:c2226020-2225631 [Bordetella parapertussis]
MLYPIHVSKDEGSAYGAAFPDFPGCFAAADELQDLPRAAQEAVEAHFYGETERIPAPSAPEAWANDEDYQGGYWMMVDID
LSKVNTKAVRLNISLPENLVHRIDEEAKARRLSRSAFLAMAAEHEMADA

Nucleotide

• Length: 390 bp

>AT137161 NZ_CP043089:c2226020-2225631 [Bordetella parapertussis]
ATGCTCTACCCGATCCATGTTTCCAAAGACGAAGGCAGCGCCTACGGGGCCGCCTTCCCTGATTTTCCCGGCTGCTTTGC
AGCCGCCGATGAACTCCAGGACCTCCCCCGCGCGGCGCAGGAAGCCGTTGAGGCGCACTTCTACGGAGAGACCGAGCGTA
TCCCCGCCCCGTCCGCCCCTGAAGCGTGGGCCAACGATGAGGACTATCAAGGCGGCTATTGGATGATGGTCGATATCGAC
CTGTCGAAGGTCAACACGAAGGCCGTGCGGCTCAACATCAGCCTGCCGGAAAACCTGGTTCACCGTATCGACGAGGAAGC
CAAGGCACGACGCCTTTCGCGCTCAGCGTTTCTGGCCATGGCTGCGGAGCACGAAATGGCCGACGCCTAG

Structures

Toxin

• AlphaFold DB: K0M8J0

Antitoxin

• AlphaFold DB: K0MFV7