Detailed information of TA system TA137140

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2441883..2442477
• Replicon: chromosome
• Accession: NZ_CP043085
• Organism: Bordetella parapertussis strain J291

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: K0M8J0
• Locus tag: FYB38_RS11505
• Protein ID: WP_010928352.1
• Coordinates: 2441883..2442065 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: K0MFV7
• Locus tag: FYB38_RS11510
• Protein ID: WP_010928351.1
• Coordinates: 2442088..2442477 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB38_RS11485	2436886..2437626	+	741	WP_003809659.1	carbonic anhydrase	-
FYB38_RS11490	2437638..2438993	-	1356	WP_003809657.1	cytochrome c	-
FYB38_RS11495	2439004..2440773	-	1770	WP_010928353.1	GMC family oxidoreductase	-
FYB38_RS11500	2440777..2441475	-	699	WP_003809653.1	gluconate 2-dehydrogenase subunit 3 family protein	-
FYB38_RS11505	2441883..2442065	+	183	WP_010928352.1	type II toxin-antitoxin system HicA family toxin	Toxin
FYB38_RS11510	2442088..2442477	+	390	WP_010928351.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FYB38_RS11520	2442743..2443519	-	777	WP_033448479.1	phosphate ABC transporter ATP-binding protein PstB	-
FYB38_RS11525	2443564..2444421	-	858	WP_003809638.1	phosphate ABC transporter permease PstA	-
FYB38_RS11530	2444443..2445459	-	1017	WP_010928350.1	phosphate ABC transporter permease subunit PstC	-
FYB38_RS11535	2445594..2446634	-	1041	WP_003809635.1	phosphate ABC transporter substrate-binding protein PstS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6750.76 Da
• Isoelectric Point: 11.4018

>T137140 WP_010928352.1 NZ_CP043085:2441883-2442065 [Bordetella parapertussis]
MNSTDLIQQPKADGWYRVHTVGSHHQYKHPTKPGKVTVPHPRKGLPTATQRSILKQAGLR

Nucleotide

• Length: 183 bp

>T137140 NZ_CP056530:679234-679611 [Klebsiella pneumoniae]
ATGCAAACCCAACCACTATCCTCAACTCAGGAGGCTACACCACGCCCGTCACCGGTGGAGATCTGGCAACGGCTTCTGAG
CCACCTGTTGGATCGTCACTACGGTCTGACACTCAACGACACTCCGTTCGGCAACGATGGCGTGATTCAGGAGCATATCG
ACGCCGGTATCTCACTGTGCGACGCGGTGAATTTTATCGTGGAGAAATACGATCTGGTACGAACCGACCGTCGCGGTTTT
AACGCAGAAACACAGTCGCCTCTTCTCAGCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGACTGATGACCCGAAA
CGATTACAGAACGGTGACCGACATCACCACCGGTAAATACCGGGAGGTGCAGCCATGA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 14270.92 Da
• Isoelectric Point: 4.3014

>AT137140 WP_010928351.1 NZ_CP043085:2442088-2442477 [Bordetella parapertussis]
MLYPIHVSKDEGSAYGAAFPDFPGCFAAADELQDLPRAAQEAVEAHFYGETERIPAPSAPEAWANDEDYQGGYWMMVDID
LSKVNTKAVRLNISLPENLVHRIDEEAKARRLSRSAFLAMAAEHEMADA

Nucleotide

• Length: 390 bp

>AT137140 NZ_CP043085:2442088-2442477 [Bordetella parapertussis]
ATGCTCTACCCGATCCATGTTTCCAAAGACGAAGGCAGCGCCTACGGGGCCGCCTTCCCTGATTTTCCCGGCTGCTTTGC
AGCCGCCGATGAACTCCAGGACCTCCCCCGCGCGGCGCAGGAAGCCGTTGAGGCGCACTTCTACGGAGAGACCGAGCGTA
TCCCCGCCCCGTCCGCCCCTGAAGCGTGGGCCAACGATGAGGACTATCAAGGCGGCTATTGGATGATGGTCGATATCGAC
CTGTCGAAGGTCAACACGAAGGCCGTGCGGCTCAACATCAGCCTGCCGGAAAACCTGGTTCACCGTATCGACGAGGAAGC
CAAGGCACGACGCCTTTCGCGCTCAGCGTTTCTGGCCATGGCTGCGGAGCACGAAATGGCCGACGCCTAG

Structures

Toxin

• AlphaFold DB: K0M8J0

Antitoxin

• AlphaFold DB: K0MFV7