Detailed information of TA system TA137135

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2441878..2442472
• Replicon: chromosome
• Accession: NZ_CP043084
• Organism: Bordetella parapertussis strain J292

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: K0M8J0
• Locus tag: FYB39_RS11505
• Protein ID: WP_010928352.1
• Coordinates: 2441878..2442060 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: K0MFV7
• Locus tag: FYB39_RS11510
• Protein ID: WP_010928351.1
• Coordinates: 2442083..2442472 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB39_RS11485	2436881..2437621	+	741	WP_003809659.1	carbonic anhydrase	-
FYB39_RS11490	2437633..2438988	-	1356	WP_003809657.1	cytochrome c	-
FYB39_RS11495	2438999..2440768	-	1770	WP_010928353.1	GMC family oxidoreductase	-
FYB39_RS11500	2440772..2441470	-	699	WP_003809653.1	gluconate 2-dehydrogenase subunit 3 family protein	-
FYB39_RS11505	2441878..2442060	+	183	WP_010928352.1	type II toxin-antitoxin system HicA family toxin	Toxin
FYB39_RS11510	2442083..2442472	+	390	WP_010928351.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FYB39_RS11520	2442738..2443514	-	777	WP_033448479.1	phosphate ABC transporter ATP-binding protein PstB	-
FYB39_RS11525	2443559..2444416	-	858	WP_003809638.1	phosphate ABC transporter permease PstA	-
FYB39_RS11530	2444438..2445454	-	1017	WP_010928350.1	phosphate ABC transporter permease subunit PstC	-
FYB39_RS11535	2445589..2446629	-	1041	WP_003809635.1	phosphate ABC transporter substrate-binding protein PstS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6750.76 Da
• Isoelectric Point: 11.4018

>T137135 WP_010928352.1 NZ_CP043084:2441878-2442060 [Bordetella parapertussis]
MNSTDLIQQPKADGWYRVHTVGSHHQYKHPTKPGKVTVPHPRKGLPTATQRSILKQAGLR

Nucleotide

• Length: 183 bp

>T137135 NZ_CP056516:98307-98618 [Citrobacter freundii]
ATGCACGTTGTATCGAGAGCACCTTTCGATACAGCCACCAGGCAATTCCCCAATCAGGCAGCGGCACTAGACGACGTATA
CCGGACTTTGAAGAGAGAGAACTACACTTCACCGGACGAAATGAAAAAACGATTTGCCTCGCTGGACAGAATGAAATATC
GGGAGAAGTGGTGGGTGATCGATGTTGGCGGTGGGAATTTAAGGGTGATGTTTTTTGCTGATTTTGAACGTGGGAAAATC
TTTATAAAGCACATAACCACACACGCCGAATACGACAAGCTGACAGATTTTTACCGGAGAACTAAAGAATGA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 14270.92 Da
• Isoelectric Point: 4.3014

>AT137135 WP_010928351.1 NZ_CP043084:2442083-2442472 [Bordetella parapertussis]
MLYPIHVSKDEGSAYGAAFPDFPGCFAAADELQDLPRAAQEAVEAHFYGETERIPAPSAPEAWANDEDYQGGYWMMVDID
LSKVNTKAVRLNISLPENLVHRIDEEAKARRLSRSAFLAMAAEHEMADA

Nucleotide

• Length: 390 bp

>AT137135 NZ_CP043084:2442083-2442472 [Bordetella parapertussis]
ATGCTCTACCCGATCCATGTTTCCAAAGACGAAGGCAGCGCCTACGGGGCCGCCTTCCCTGATTTTCCCGGCTGCTTTGC
AGCCGCCGATGAACTCCAGGACCTCCCCCGCGCGGCGCAGGAAGCCGTTGAGGCGCACTTCTACGGAGAGACCGAGCGTA
TCCCCGCCCCGTCCGCCCCTGAAGCGTGGGCCAACGATGAGGACTATCAAGGCGGCTATTGGATGATGGTCGATATCGAC
CTGTCGAAGGTCAACACGAAGGCCGTGCGGCTCAACATCAGCCTGCCGGAAAACCTGGTTCACCGTATCGACGAGGAAGC
CAAGGCACGACGCCTTTCGCGCTCAGCGTTTCTGGCCATGGCTGCGGAGCACGAAATGGCCGACGCCTAG

Structures

Toxin

• AlphaFold DB: K0M8J0

Antitoxin

• AlphaFold DB: K0MFV7