Detailed information of TA system TA137132

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4395899..4396493
• Replicon: chromosome
• Accession: NZ_CP043083
• Organism: Bordetella parapertussis strain J293

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: K0M8J0
• Locus tag: FYB40_RS20705
• Protein ID: WP_010928352.1
• Coordinates: 4395899..4396081 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: K0MFV7
• Locus tag: FYB40_RS20710
• Protein ID: WP_010928351.1
• Coordinates: 4396104..4396493 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB40_RS20685	4390902..4391642	+	741	WP_003809659.1	carbonic anhydrase	-
FYB40_RS20690	4391654..4393009	-	1356	WP_003809657.1	cytochrome c	-
FYB40_RS20695	4393020..4394789	-	1770	WP_010928353.1	GMC family oxidoreductase	-
FYB40_RS20700	4394793..4395491	-	699	WP_003809653.1	gluconate 2-dehydrogenase subunit 3 family protein	-
FYB40_RS20705	4395899..4396081	+	183	WP_010928352.1	type II toxin-antitoxin system HicA family toxin	Toxin
FYB40_RS20710	4396104..4396493	+	390	WP_010928351.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FYB40_RS20720	4396759..4397535	-	777	WP_033448479.1	phosphate ABC transporter ATP-binding protein PstB	-
FYB40_RS20725	4397580..4398437	-	858	WP_003809638.1	phosphate ABC transporter permease PstA	-
FYB40_RS20730	4398459..4399475	-	1017	WP_010928350.1	phosphate ABC transporter permease subunit PstC	-
FYB40_RS20735	4399610..4400650	-	1041	WP_003809635.1	phosphate ABC transporter substrate-binding protein PstS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6750.76 Da
• Isoelectric Point: 11.4018

>T137132 WP_010928352.1 NZ_CP043083:4395899-4396081 [Bordetella parapertussis]
MNSTDLIQQPKADGWYRVHTVGSHHQYKHPTKPGKVTVPHPRKGLPTATQRSILKQAGLR

Nucleotide

• Length: 183 bp

>T137132 NZ_CP056515:c4216396-4216121 [Citrobacter freundii]
ATGGAAATTTACTGGACGCTTAAAGCTCAGGATGATCTGGAACGTATCTACCGTTTCGCCCTTCAGTACAGCCGCCAGCC
CGCCGATAACGTTTTGGATCGCCTGATTATTGGCTGTGCTGGTCTTACAGCGCATCCGGCAATTGGCGTGCAGCAGACTC
GGTATGAACCTCGGGAAGTCCGAAAAGTGTTATTCGATGACTATGAGGTTCACTACGAACTCCGTGGCAATGACATCTAT
ATCGTGGATCTCTGGCATACAAAAGAAGAGCGATGA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 14270.92 Da
• Isoelectric Point: 4.3014

>AT137132 WP_010928351.1 NZ_CP043083:4396104-4396493 [Bordetella parapertussis]
MLYPIHVSKDEGSAYGAAFPDFPGCFAAADELQDLPRAAQEAVEAHFYGETERIPAPSAPEAWANDEDYQGGYWMMVDID
LSKVNTKAVRLNISLPENLVHRIDEEAKARRLSRSAFLAMAAEHEMADA

Nucleotide

• Length: 390 bp

>AT137132 NZ_CP056515:c4216648-4216400 [Citrobacter freundii]
ATGGGTTCGCTTACTAAACAAACCATCAGCGCACAGATACCCGTTGAATTGGCCGCTGCTGTTGAAAATCTGGCAATTGA
GTTAGATCGTTCTAAAAGCTGGATCATTAAGGAAGCGTTGACCAGTATGCTGGCCGAACGAGAACGGCGTCATCAGAGTA
TCCAGGCCGGTCTTGCTGATGTGGATGCCGGTCGTGTGGTGAGTCATTCGAACATGGTGGATTTCGCTAACCGTTTAAAG
AAAGCCTGA

Structures

Toxin

• AlphaFold DB: K0M8J0

Antitoxin

• AlphaFold DB: K0MFV7