Detailed information of TA system TA137129

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 342809..343470
• Replicon: chromosome
• Accession: NZ_CP043083
• Organism: Bordetella parapertussis strain J293

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q7WAH5
• Locus tag: FYB40_RS01660
• Protein ID: WP_003812073.1
• Coordinates: 343045..343470 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FYB40_RS01655
• Protein ID: WP_003812071.1
• Coordinates: 342809..343048 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB40_RS01620	337844..338647	-	804	WP_003812055.1	bacteriocin family protein	-
FYB40_RS01625	338644..339690	-	1047	WP_010928022.1	Dyp-type peroxidase	-
FYB40_RS01630	339768..340328	-	561	WP_010928021.1	DUF488 domain-containing protein	-
FYB40_RS01635	340325..340558	-	234	WP_033447224.1	DUF2945 domain-containing protein	-
FYB40_RS01640	340639..341151	-	513	WP_003812062.1	redoxin domain-containing protein	-
FYB40_RS01645	341210..341755	-	546	WP_010928020.1	peroxidase-related enzyme	-
FYB40_RS01650	341893..342735	+	843	WP_010928019.1	AraC family transcriptional regulator	-
FYB40_RS01655	342809..343048	+	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
FYB40_RS01660	343045..343470	+	426	WP_003812073.1	PIN domain-containing protein	Toxin
FYB40_RS01665	343580..344044	+	465	WP_003812075.1	MarR family transcriptional regulator	-
FYB40_RS01670	344142..345647	-	1506	WP_010928018.1	tripartite tricarboxylate transporter permease	-
FYB40_RS01675	346146..346658	+	513	WP_010928017.1	hypothetical protein	-
FYB40_RS01680	346679..347656	-	978	WP_003812083.1	tripartite tricarboxylate transporter substrate binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14811.22 Da
• Isoelectric Point: 6.3704

>T137129 WP_003812073.1 NZ_CP043083:343045-343470 [Bordetella parapertussis]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRVLPLFMGHVLPFDT
AAADAYAAVMMRAAAAGHALCAIDGCIAAIATAHGLAIATRHPARFEAAGLAAVDPWHAAA

Nucleotide

• Length: 426 bp

>T137129 NZ_CP043083:343045-343470 [Bordetella parapertussis]
ATGATCCTGCTCGACACCGACGTGCTGCTCGAGCCGCTGCGGCCGGCCCCCGACCCGGCCGTCGCGGCATGGCTGGATGC
CCAGCACGTCGAAACCCTGTACCTGGCCGCGCCCGGCGCGGCCGAAATCCAGCTCGGGCTGGCCCGCCTGCCGCGCGGCA
AGCGGGCCGAGGCCTTGCGCCACGAATTCGAGCGGCGCGTCCTGCCGCTGTTCATGGGCCATGTCCTGCCCTTCGACACG
GCCGCGGCCGATGCCTACGCCGCCGTCATGATGCGGGCCGCGGCGGCGGGCCATGCGCTGTGCGCAATCGATGGTTGCAT
CGCCGCCATCGCCACCGCGCACGGCCTGGCCATCGCCACGCGCCATCCGGCCAGGTTCGAGGCGGCCGGGCTCGCCGCCG
TCGATCCCTGGCACGCCGCCGCTTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT137129 WP_003812071.1 NZ_CP043083:342809-343048 [Bordetella parapertussis]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT137129 NZ_CP043083:342809-343048 [Bordetella parapertussis]
GTGTCTTCGATTACGGTAAGAAATGTTCCCGAGGAAGTGCATCGCGCCTTGCGCGTACGCGCGGCCACGCATGGGCGCAG
CACCGAGGCCGAGATCCGCGCCATCCTGGAAAACGCCGTGCTGCCCGATGGCCGCGTCAAGCTGGGCACCCTGCTCAGCC
ACATCGGCCGCGGCGCGCGCGGCATGGACCTGACCATCGAGCGCAATCCGGCGCCCGCTCGCCCGGCCAGCTTCGAATGA

Structures

Toxin

• AlphaFold DB: Q7WAH5