Detailed information of TA system TA137127

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2022415..2023009
• Replicon: chromosome
• Accession: NZ_CP043082
• Organism: Bordetella parapertussis strain J297

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: K0M8J0
• Locus tag: FYB41_RS09580
• Protein ID: WP_010928352.1
• Coordinates: 2022827..2023009 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: K0MFV7
• Locus tag: FYB41_RS09575
• Protein ID: WP_010928351.1
• Coordinates: 2022415..2022804 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB41_RS09550	2018258..2019298	+	1041	WP_003809635.1	phosphate ABC transporter substrate-binding protein PstS	-
FYB41_RS09555	2019433..2020449	+	1017	WP_010928350.1	phosphate ABC transporter permease subunit PstC	-
FYB41_RS09560	2020471..2021328	+	858	WP_003809638.1	phosphate ABC transporter permease PstA	-
FYB41_RS09565	2021373..2022149	+	777	WP_033448479.1	phosphate ABC transporter ATP-binding protein PstB	-
FYB41_RS09575	2022415..2022804	-	390	WP_010928351.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FYB41_RS09580	2022827..2023009	-	183	WP_010928352.1	type II toxin-antitoxin system HicA family toxin	Toxin
FYB41_RS09585	2023417..2024115	+	699	WP_003809653.1	gluconate 2-dehydrogenase subunit 3 family protein	-
FYB41_RS09590	2024119..2025888	+	1770	WP_010928353.1	GMC family oxidoreductase	-
FYB41_RS09595	2025899..2027254	+	1356	WP_003809657.1	cytochrome c	-
FYB41_RS09600	2027266..2028006	-	741	WP_003809659.1	carbonic anhydrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6750.76 Da
• Isoelectric Point: 11.4018

>T137127 WP_010928352.1 NZ_CP043082:c2023009-2022827 [Bordetella parapertussis]
MNSTDLIQQPKADGWYRVHTVGSHHQYKHPTKPGKVTVPHPRKGLPTATQRSILKQAGLR

Nucleotide

• Length: 183 bp

>T137127 NZ_CP043082:c2023009-2022827 [Bordetella parapertussis]
ATGAACAGCACAGACCTGATCCAGCAACCGAAGGCCGACGGCTGGTATCGCGTGCATACCGTGGGTTCACACCACCAGTA
CAAGCACCCGACCAAGCCCGGCAAGGTCACCGTGCCGCATCCCAGGAAGGGCCTGCCGACAGCGACACAGCGCAGCATCC
TTAAGCAAGCCGGCCTGCGATAA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 14270.92 Da
• Isoelectric Point: 4.3014

>AT137127 WP_010928351.1 NZ_CP043082:c2022804-2022415 [Bordetella parapertussis]
MLYPIHVSKDEGSAYGAAFPDFPGCFAAADELQDLPRAAQEAVEAHFYGETERIPAPSAPEAWANDEDYQGGYWMMVDID
LSKVNTKAVRLNISLPENLVHRIDEEAKARRLSRSAFLAMAAEHEMADA

Nucleotide

• Length: 390 bp

>AT137127 NZ_CP056515:906501-906767 [Citrobacter freundii]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGTCGCGGTATGCGTGAGCTGGACATTTCGATCATGCCGTT
TTTCGAACATGAGTATGACAACTTAAGTGATGACGAAAAGCGCATTTTTATCCGTTTGCTGGAATGTGATGACCCCGATT
TATTTAACTGGTTGATGAATCACGGGAAGCCGGCTGATGCACAGCTGGAGCAAATGGTACGGCTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: K0M8J0

Antitoxin

• AlphaFold DB: K0MFV7